(2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile

Base Information

• Chemical Name: (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile
• CAS No.: 76322-12-8
• Molecular Formula: C₁₃H₁₅NO₅
• Molecular Weight: 265.266
• Mol file: 76322-12-8.mol

Synonyms:

Chemical Property of (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile

There total 4 articles about (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile (76322-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / potassium carbonate, potassium iodide / 4 h / Heating

2: 1.) potassium metabisulfite / 1.) 50 deg C, water 2.) water, ether, 5 deg C, 6 h

With potassium disulphite; potassium carbonate; potassium iodide;

DOI:10.1002/bscb.19800890607

Reference yield:

2-ethoxycarbonylmethoxy-5-methoxybenzaldehyde (76322-07-1) → (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile (76322-12-8)

Guidance literature:

With sodium hydrogensulfite; Behandeln des Reaktionsprodukts mit Natriumcyanid in Wasser;

DOI:10.1039/jr9350000993

Reference yield:

4-methoxy-phenol (150-76-5) → (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile (76322-12-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / Reimer-Tiemann reaction

2: 80 percent / potassium carbonate, potassium iodide / 4 h / Heating

3: 1.) potassium metabisulfite / 1.) 50 deg C, water 2.) water, ether, 5 deg C, 6 h

With potassium disulphite; potassium carbonate; potassium iodide;

DOI:10.1002/bscb.19800890607

upstream raw materials:

2-ethoxycarbonylmethoxy-5-methoxybenzaldehyde

sodium cyanide

2-hydroxy-5-methoxybenzaldehyde

4-methoxy-phenol

Downstream raw materials:

(2',4'-dihydroxy-5-methoxy-α'-oxo-bibenzyl-2-yloxy)-acetic acid

ethyl(2-ethoxycarbonylmethoxy-5-methoxyphenyl)acetate

6-methoxychroman-3-one

(2-Carboxymethoxy-5-methoxy-phenyl)-acetic acid

Refernces