methyl 3-bromo-2-formylbenzoate

Base Information

• Chemical Name: methyl 3-bromo-2-formylbenzoate
• CAS No.: 1287277-22-8
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.057
• Hs Code.: 2918300090
• Mol file: 1287277-22-8.mol

Synonyms:

Chemical Property of methyl 3-bromo-2-formylbenzoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-bromo-2-formylbenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-bromo-2-formylbenzoate

There total 2 articles about methyl 3-bromo-2-formylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-bromo-2-formylbenzoic acid + methyl iodide (74-88-4) → methyl 3-bromo-2-formylbenzoate (1287277-22-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00676

Reference yield:

4-bromoisobenzofuran-1(3H)-one (102308-43-0) → methyl 3-bromo-2-formylbenzoate (1287277-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 1 h / 85 °C / Inert atmosphere

1.2: 1 h / 100 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.5b00676

Reference yield:

methyl 3-bromo-2-formylbenzoate (1287277-22-8) → 4-bromo-3-(1-hydroxy-2-oxopropyl)-2-(4-methoxyphenyl)isoindolin-1-one + (+)-4-bromo-3-(1-hydroxy-2-oxopropyl)-2-(4-methoxyphenyl)isoindolin-1-one

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.1: L-proline / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

With L-proline; In N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.5b00676

upstream raw materials:

4-bromoisobenzofuran-1(3H)-one

methyl iodide