3-hydroxymethylene-6-bromooxindole

Base Information

• Chemical Name: 3-hydroxymethylene-6-bromooxindole
• CAS No.: 99365-41-0
• Molecular Formula: C₉H₆BrNO₂
• Molecular Weight: 240.056
• Mol file: 99365-41-0.mol

Synonyms:

Chemical Property of 3-hydroxymethylene-6-bromooxindole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxymethylene-6-bromooxindole

There total 6 articles about 3-hydroxymethylene-6-bromooxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

6-bromo-2,3-dihydro-1H-indole-2-one (99365-40-9) + formic acid ethyl ester (109-94-4) → 3-hydroxymethylene-6-bromooxindole (99365-41-0)

Guidance literature:

With sodium ethanolate; 1.) room temp., 1 h; 2.) 90 deg C, 0.5 h;

DOI:10.1248/cpb.33.1414

Reference yield:

(4-bromo-2-nitrophenyl)acetic acid (6127-11-3) → 3-hydroxymethylene-6-bromooxindole (99365-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Zn, H₂SO₄ (50percent) / ethanol / 3 h / 90 °C

2: 92.1 percent / NaOEt / 1.) room temp., 1 h; 2.) 90 deg C, 0.5 h

With sulfuric acid; sodium ethanolate; zinc; In ethanol;

DOI:10.1248/cpb.33.1414

Reference yield:

4-bromo-2-nitrotoluene (60956-26-5) → 3-hydroxymethylene-6-bromooxindole (99365-41-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium ethoxide / 1.) room temp., overnight; 2.) reflux, 10 min

2: H₂O / 2 h / Heating

3: 85.4 percent / H₂O₂ (30percent), NaOH / H₂O / 1 h / 5 °C

4: 97 percent / Zn, H₂SO₄ (50percent) / ethanol / 3 h / 90 °C

5: 92.1 percent / NaOEt / 1.) room temp., 1 h; 2.) 90 deg C, 0.5 h

With sodium hydroxide; sulfuric acid; dihydrogen peroxide; sodium ethanolate; zinc; In ethanol; water;

DOI:10.1248/cpb.33.1414

upstream raw materials:

6-bromo-2,3-dihydro-1H-indole-2-one

formic acid ethyl ester

(4-bromo-2-nitrophenyl)acetic acid

4-bromo-2-nitrotoluene