O-Methyl Chlorthalidone

Base Information

• Chemical Name: O-Methyl Chlorthalidone
• CAS No.: 96512-76-4
• Molecular Formula: C₁₅H₁₃ClN₂O₄S
• Molecular Weight: 352.798
• Mol file: 96512-76-4.mol

Synonyms:

Chemical Property of O-Methyl Chlorthalidone

Chemical Property:

• Melting Point: >121°C (dec.)
• PKA: 9.57±0.60(Predicted)
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

O-MethylChlorthalidone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: O-Methyl Chlorthalidone is an impurity of Chlorthalidone (C427500), a diuretic and antihypertensive agent.

Technology Process of O-Methyl Chlorthalidone

There total 4 articles about O-Methyl Chlorthalidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) → Chlortalidon-methylether (74722-84-2,74722-85-3,96512-76-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1002/hlca.19590420344

Reference yield:

methanol (67-56-1) + chlorthalidon (77-36-1) → Chlortalidon-methylether (74722-84-2,74722-85-3,96512-76-4)

Guidance literature:

With ethylenediaminetetraacetic acid; iron(III) chloride; acetic acid; nickel dichloride; Povidone; at 41 ℃; Rate constant; rate constant without and with reagents;

DOI:10.1002/jps.2600740811

Reference yield:

Chlortalidon-methylether (74722-84-2,74722-85-3,96512-76-4) → (-)-Chlortalidon-methylether (74658-79-0,74722-84-2,74722-85-3,96512-76-4)

Guidance literature:

Yield given;

DOI:10.1002/cber.19801130538

upstream raw materials:

methanol

chlorthalidon

Chlortalidon-methylether

Downstream raw materials:

(-)-Chlortalidon-methylether

Refernces

• 1、 Blaschke,Markgraf. "Chromatographic resolutions of racemates, IX. Chlorotalidone-, chlorotalidone methyl ether-, and oxazepam enantiomers". . p. 2031 - 2035. Retrieved 2007/10/02.