1-(1-Naphthyl)-2-naphthoic acid

Base Information

• Chemical Name: 1-(1-Naphthyl)-2-naphthoic acid
• CAS No.: 18795-02-3
• Molecular Formula: C₂₁H₁₄O₂
• Molecular Weight: 298.341
• DSSTox Substance ID: DTXSID00475133
• Nikkaji Number: J1.989.149F
• Mol file: 18795-02-3.mol

Synonyms:1-(1-Naphthyl)-2-naphthoic acid;1-naphthalen-1-ylnaphthalene-2-carboxylic Acid;18795-02-3;(S)-[1,1'-Binaphthalene]-2-carboxylic acid;80317-68-6;[1,1'-Binaphthalene]-2-carboxylic acid;SCHEMBL9124028;DTXSID00475133;DMWVMIJYUWUJBM-UHFFFAOYSA-N;1,1'-Binaphthalene-2-carboxylic acid;1-naphthyl-naphthalene-2-carboxylic acid;(R)-[1,1'-Binaphthalene]-2-carboxylic acid;127760-83-2

Chemical Property of 1-(1-Naphthyl)-2-naphthoic acid

Chemical Property:

• XLogP3: 5.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 298.099379685
• Heavy Atom Count: 23
• Complexity: 432

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2C3=C(C=CC4=CC=CC=C43)C(=O)O

Technology Process of 1-(1-Naphthyl)-2-naphthoic acid

There total 48 articles about 1-(1-Naphthyl)-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(1-naphthyl)-naphthalene-2-carbaldehyde (80409-67-2) → racemic 1,1'-binaphthyl-2-carboxylic acid (18795-02-3,80317-68-6,127760-83-2)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 3.5h;

DOI:10.1246/bcsj.20180081

Reference yield: 91.0%

1-Bromonaphthalene (90-11-9) + 1-methoxy-2-naphthoic acid (883-21-6) → racemic 1,1'-binaphthyl-2-carboxylic acid (18795-02-3,80317-68-6,127760-83-2)

Guidance literature:

1-Bromonaphthalene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

1-methoxy-2-naphthoic acid; In tetrahydrofuran; at -30 ℃; for 16h;

DOI:10.1021/jo202017z

Reference yield: 87.0%

1-Bromonaphthalene (90-11-9) + 1-fluoronaphthalene-2-carboxylic acid (574-97-0) → racemic 1,1'-binaphthyl-2-carboxylic acid (18795-02-3,80317-68-6,127760-83-2)

Guidance literature:

1-Bromonaphthalene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

1-fluoronaphthalene-2-carboxylic acid; In tetrahydrofuran; at -30 ℃; for 2h;

DOI:10.1021/jo202017z

upstream raw materials:

[1,1']Binaphthalenyl-2-carboxylic acid methyl ester

racemic 2-<2-(1,1'-binaphthylyl)>-4,4-dimethyl-Δ²-oxazoline

methyl iodide

1-(1-naphthyl)-naphthalene-2-carbaldehyde