N3-PEG7-OH

Base Information

• Chemical Name: N3-PEG7-OH
• CAS No.: 1274892-60-2
• Molecular Formula: C₁₄H₂₉N₃O₇
• Molecular Weight: 351.4
• Mol file: 1274892-60-2.mol

Synonyms:

Chemical Property of N3-PEG7-OH

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98.5% ^*data from raw suppliers

Azido-PEG7-alcohol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG7-alcohol is a aqueous soluble PEGylation reagent The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Hydroxy group further increase the reagnt's water solubility.

Technology Process of N3-PEG7-OH

There total 11 articles about N3-PEG7-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C14H28O10S → 2-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol (1274892-60-2)

Guidance literature:

C₁₄H₂₈O₁₀S; With sodium azide; In N,N-dimethyl-formamide; at 80 ℃;

With sulfuric acid; In tetrahydrofuran; water; Reflux;

DOI:10.1039/c6ob01286h

Reference yield: 95.41%

Toluene-4-sulfonic acid 2-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethyl ester (1028089-05-5) → 2-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol (1274892-60-2)

Guidance literature:

With sodium azide; In acetonitrile; at 80 ℃; for 12h;

Reference yield:

19-(triphenylmethyl)-1,4,7,10,13,16,19-heptaoxanonadecanol (127999-16-0) → 2-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol (1274892-60-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 97 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2.1: t-BuOK / 2-methyl-propan-2-ol / 0.5 h / Heating

2.2: 94 percent / 2-methyl-propan-2-ol / 4 h / Heating

3.1: 81 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

4.1: 80 percent / NaN₃ / acetonitrile / Heating

5.1: TsOH; methanol / 2 h / Heating

With methanol; sodium azide; potassium tert-butylate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; acetonitrile; tert-butyl alcohol;

DOI:10.1021/jm040800a

upstream raw materials:

22-azido-1,1,1-triphenyl-2,5,8,11,14,17,20-heptaoxadocosane

19-(triphenylmethyl)-1,4,7,10,13,16,19-heptaoxanonadecanol

10,10,10-triphenyl-3,6,9-trioxadecan-1-ol

1-(methylsulfonyl)-10-(triphenylcarbinyl)-1,4,7,10-tetraoxadecane