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127999-16-0

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127999-16-0 Usage

Description

Tr-PEG7 is a PEG linker containing a trityl alcohol protecting group. The trityl group can be removed under acidic conditions or through hydrogenolysis. The hydrophilic PEG linker increases the water solubility properties of compounds. Increasing the number of ethylene glycol units within a PEG chain improves their water solubility properties.

Check Digit Verification of cas no

The CAS Registry Mumber 127999-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,9,9 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 127999-16:
(8*1)+(7*2)+(6*7)+(5*9)+(4*9)+(3*9)+(2*1)+(1*6)=180
180 % 10 = 0
So 127999-16-0 is a valid CAS Registry Number.

127999-16-0Relevant articles and documents

A-B-A-B-A block amphiphiles. Balance between hydrophilic and hydrophobic segmentation

Menger, Fredric M.,Lu, Hao,Lundberg, Dan

, p. 272 - 273 (2007)

Six penta-block amphiphiles of the general structure A-B-A-B-A or B-A-B-A-B (where A = a hydrophilic ether and B = a hydrophobic carbon chain) were synthesized and examined via water solubilities, surface activities, cloud points, and self-diffusion coeff

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

Zhang, Hua,Li, Xuefei,Shi, Qiuyan,Li, Yu,Xia, Guiquan,Chen, Long,Yang, Zhigang,Jiang, Zhong-Xing

, p. 3763 - 3767 (2015/03/18)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.

HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF

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Page/Page column 35; 36, (2013/07/05)

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

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