Technology Process of 2-((2-methoxy-4-pyridinyl)methyl)piperazine
There total 8 articles about 2-((2-methoxy-4-pyridinyl)methyl)piperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-((2-methoxy-4-pyridinyl)methyl)-2,5-piperazinedione;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 70 ℃;
for 2h;
With
sodium hydroxide;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 °C
2: sodium hydroxide / tetrahydrofuran / 24 h / 20 °C
3: hydrogenchloride; water / tetrahydrofuran / 2 h / 0 °C
4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
5: trifluoroacetic acid / dichloromethane / 2 h / 0 °C
6: N-ethyl-N,N-diisopropylamine / methanol / 18 h / 70 °C
7: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C
With
hydrogenchloride; carbon tetrabromide; dimethylsulfide borane complex; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 70 °C
1.2: 0 °C
2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 °C
3.1: sodium hydroxide / tetrahydrofuran / 24 h / 20 °C
4.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 0 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C
7.1: N-ethyl-N,N-diisopropylamine / methanol / 18 h / 70 °C
8.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C
With
hydrogenchloride; carbon tetrabromide; dimethylsulfide borane complex; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
