4-(broMoMethyl)-2-Methoxypyridine

Base Information

• Chemical Name: 4-(broMoMethyl)-2-Methoxypyridine
• CAS No.: 120277-15-8
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 2933399090
• Mol file: 120277-15-8.mol

Synonyms:4-(broMoMethyl)-2-Methoxypyridine

Chemical Property of 4-(broMoMethyl)-2-Methoxypyridine

Chemical Property:

• Boiling Point: 250.2±25.0 °C(Predicted)
• PKA: 2.99±0.10(Predicted)
• PSA: 22.12000
• Density: 1.484±0.06 g/cm3(Predicted)
• LogP: 1.98510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Bromomethyl-2-methoxypyridine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(broMoMethyl)-2-Methoxypyridine

There total 4 articles about 4-(broMoMethyl)-2-Methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methoxy-4-(hydroxymethyl)-pyridine (123148-66-3) → 4-(bromomethyl)-2-methoxypyridine (120277-15-8)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 70.0%

→ 4-(bromomethyl)-2-methoxypyridine (120277-15-8)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;

Reference yield:

methyl 2-methoxyisonicotinate (26156-51-4) → 4-(bromomethyl)-2-methoxypyridine (120277-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 70 °C

1.2: 0 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 °C

With carbon tetrabromide; dimethylsulfide borane complex; triphenylphosphine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2-methoxy-4-(hydroxymethyl)-pyridine

methyl 2-methoxyisonicotinate

2-methoxy-isonicotinic acid

Downstream raw materials:

1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-4-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

2-((2-methoxy-4-pyridinyl)methyl)piperazine

Refernces

• 1、 -. "Substituted Pyrrolidine Amides I". Paragraph 0343-0344. . Retrieved 2019/07/03.
• 2、 -. "N-methyl tetrahydroquinoline M1 receptor positive allosteric modulators". . . Retrieved 2016/04/05.