[[3-Methoxy-4-(phenylMethoxy)phenyl]Methylene]butanedioic Acid Ethyl Ester

Base Information

• Chemical Name: [[3-Methoxy-4-(phenylMethoxy)phenyl]Methylene]butanedioic Acid Ethyl Ester
• CAS No.: 1391062-42-2
• Molecular Formula: C₂₁H₂₂O₆
• Molecular Weight: 370.402
• Mol file: 1391062-42-2.mol

Synonyms:

Chemical Property of [[3-Methoxy-4-(phenylMethoxy)phenyl]Methylene]butanedioic Acid Ethyl Ester

Chemical Property:

Purity/Quality:

[[4-Benzyloxy-3-methoxyphenyl]methylene]butanedioicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [[3-Methoxy-4-(phenylMethoxy)phenyl]Methylene]butanedioic Acid Ethyl Ester

There total 3 articles about [[3-Methoxy-4-(phenylMethoxy)phenyl]Methylene]butanedioic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + succinic acid diethyl ester (123-25-1) → C21H22O6 (1391062-42-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 4h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2015.09.039

Reference yield:

benzyl bromide (100-39-0) → C21H22O6 (1391062-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 4 h / Inert atmosphere; Reflux

With sodium ethanolate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 2: |Stobbe Condensation;

DOI:10.1016/j.bmc.2015.09.039

Reference yield:

vanillin (121-33-5,8014-42-4) → C21H22O6 (1391062-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 4 h / Inert atmosphere; Reflux

With sodium ethanolate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 2: |Stobbe Condensation;

DOI:10.1016/j.bmc.2015.09.039

upstream raw materials:

3-methoxy-4-(phenylmethoxy)benzaldehyde

succinic acid diethyl ester

benzyl bromide

vanillin

Downstream raw materials:

(E)-2-(4'-benzyloxy-3'-methoxybenzylidene)succinic acid

(2R,3R)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediol

Refernces

• 1、 Xia, Ya-Mu,You, Jia,Wang. "Total synthesis of (±)-divanillyltetrahydrofuran ferulate". scheme or table. p. 433 - 436. Retrieved 2010/12/25.