(2R)-1-(diphenylphosphino)-3-Methyl-2-ButanaMine

Base Information

• Chemical Name: (2R)-1-(diphenylphosphino)-3-Methyl-2-ButanaMine
• CAS No.: 1400149-69-0
• Molecular Formula: C₁₇H₂₂NP
• Molecular Weight: 271.342
• Mol file: 1400149-69-0.mol

Synonyms:

Chemical Property of (2R)-1-(diphenylphosphino)-3-Methyl-2-ButanaMine

Chemical Property:

• Boiling Point: 374.8±25.0 °C(Predicted)
• PKA: 9.73±0.13(Predicted)
• Density: 1.049 g/mL at 25 °C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: air sensitive

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-(Diphenylphosphino)-2-amino-3-methylbutane, min. 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-1-(diphenylphosphino)-3-Methyl-2-ButanaMine

There total 18 articles about (2R)-1-(diphenylphosphino)-3-Methyl-2-ButanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester (146476-35-9) → (2S)-1-(diphenylphosphino)-3-methylbutan-2-amine (146476-37-1,1400149-69-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/S0957-4166(01)00137-9

Reference yield: 88.0%

(S)-N-(1-(diphenylphosphanyl)-3-methylbutan-2-yl)-4-methylbenzenesulfonamide (602307-05-1) → (2S)-1-(diphenylphosphino)-3-methylbutan-2-amine (146476-37-1,1400149-69-0)

Guidance literature:

With sulfuric acid; at 100 ℃; for 5h;

DOI:10.1021/ol801259u

Reference yield: 43.0%

lithium diphenylphosphide (65567-06-8,4541-02-0) + (S)-1-(p-toluenesulfonylmethyl)-2-methyl-propylammonium bromide → (2S)-1-(diphenylphosphino)-3-methylbutan-2-amine (146476-37-1,1400149-69-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/S0040-4020(99)01075-3

upstream raw materials:

(1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester

lithium diphenylphosphide

(S)-2-(N-tert-butoxycarbonylamino)-3-methylbutyl tosylate

(S)-valinol

Downstream raw materials:

{(S)-1-[(Diphenylphosphanyl)-methyl]-2-methyl-propyl}-isopropylidene-amine