methyl-3,5-difluoro-4-formyl benzoate

Base Information

• Chemical Name: methyl-3,5-difluoro-4-formyl benzoate
• CAS No.: 1415124-73-0
• Molecular Formula: C₉H₆F₂O₃
• Molecular Weight: 200.142
• Hs Code.: 2918300090

Synonyms:

Chemical Property of methyl-3,5-difluoro-4-formyl benzoate

Chemical Property:

• Boiling Point: 293.7±40.0 °C(Predicted)
• Density: 1.357±0.06 g/cm3(Predicted)

Purity/Quality:

99%+ ^*data from raw suppliers

Methyl3,5-difluoro-4-formylbenzoate 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of methyl-3,5-difluoro-4-formyl benzoate

There total 3 articles about methyl-3,5-difluoro-4-formyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + methyl 3,5-difluorobenzoate (216393-55-4) → methyl-3,5-difluoro-4-formyl benzoate (1415124-73-0)

Guidance literature:

methyl 3,5-difluorobenzoate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.05.093

Reference yield: 33.0%

3,5-difluoro-4-formylbenzoic acid (736990-88-8) + methyl iodide (74-88-4) → methyl-3,5-difluoro-4-formyl benzoate (1415124-73-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

3,5-difluorobenzoic acid (455-40-3) → methyl-3,5-difluoro-4-formyl benzoate (1415124-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran / 1 h / -78 °C

2.2: -78 - 20 °C

With oxalyl dichloride; lithium diisopropyl amide; N,N-dimethyl-formamide; In tetrahydrofuran; n-heptane; dichloromethane;

upstream raw materials:

N,N-dimethyl-formamide

methyl 3,5-difluorobenzoate

3,5-difluorobenzoic acid

3,5-difluoro-4-formylbenzoic acid

Downstream raw materials:

3,5-difluoro-4-formyl-N-methylbenzamide

methyl (S)-2-((2-(2,6-difluoro-4-(4-methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

(R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate

tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

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