3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid

Base Information

• Chemical Name: 3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid
• CAS No.: 128043-92-5
• Molecular Formula: C₁₂H₉ClN₂O₅
• Molecular Weight: 296.667
• Mol file: 128043-92-5.mol

Synonyms:

Chemical Property of 3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid

Chemical Property:

• Boiling Point: 556.8±40.0 °C(Predicted)
• PKA: 3.14±0.10(Predicted)
• Density: 1.623±0.06 g/cm3(Predicted)

Purity/Quality:

2-[3-(2-Chlorobenzyl)-2,4,5-trioxo-1-imidazolidinyl]acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid

There total 5 articles about 3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-chlorophenyl)methylurea (4654-63-1) → 3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid (128043-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / Ambient temperature

2: KOH / ethanol / 8 h / Heating

3: conc. HCl, AcOH / 4.5 h / Heating

With hydrogenchloride; potassium hydroxide; acetic acid; In tetrahydrofuran; ethanol;

DOI:10.1021/jm9508393

Reference yield:

(2-chlorophenyl)methanamine monohydrochloride (22680-44-0) → 3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid (128043-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: conc. HCl / H₂O / 3 h / Heating

2: tetrahydrofuran / 3 h / Ambient temperature

3: KOH / ethanol / 8 h / Heating

4: conc. HCl, AcOH / 4.5 h / Heating

With hydrogenchloride; potassium hydroxide; acetic acid; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm9508393

Reference yield:

1-(2-chlorobenzyl)imidazolidinetrione (105686-01-9) → 3-Carboxymethyl-1-(2-chlorobenzyl)parabanic acid (128043-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol / 8 h / Heating

2: conc. HCl, AcOH / 4.5 h / Heating

With hydrogenchloride; potassium hydroxide; acetic acid; In ethanol;

DOI:10.1021/jm9508393

upstream raw materials:

ethyl 1-(2-chlorobenzyl)-2,4,5-trioxoimidazolidine-3-acetate

1-(2-chlorophenyl)methylurea

(2-chlorophenyl)methanamine monohydrochloride

1-(2-chlorobenzyl)imidazolidinetrione