DM-4128

Base Information

• Chemical Name: DM-4128
• CAS No.: 1432725-24-0
• Molecular Formula: C₁₈H₁₉ClN₂O₂
• Molecular Weight: 330.814
• Mol file: 1432725-24-0.mol

Synonyms:

Chemical Property of DM-4128

Chemical Property:

• Boiling Point: 565.4±50.0 °C(Predicted)
• Density: 1.325±0.06 g/cm3(Predicted)

Purity/Quality:

98.5% ^*data from raw suppliers

2-DesmethylbenzaldehydeTolvaptan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Desmethylbenzaldehyde Tolvaptan is an impurity of the drug Tolvaptan (T536650). Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia.

Technology Process of DM-4128

There total 4 articles about DM-4128 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tolvaptan (150683-30-0) → 7-chloro-2,3-dihydro-1H-benzo[b]azepine (1316312-24-9) + DM-4128 (1432725-24-0) + (4-amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone + 2-methyl-4-(2-methylbenzoylamino)benzoic acid (317374-08-6)

Guidance literature:

With hydrogenchloride; water; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1039/c4ra16644b

Reference yield:

tolvaptan (150683-30-0) → DM-4128 (1432725-24-0) + N-(4-(7-chloro-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide + 2-methyl-4-(2-methylbenzoylamino)benzoic acid (317374-08-6)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 80 ℃; for 17h;

DOI:10.1039/c4ra16644b

Reference yield:

methanol (67-56-1) + tolvaptan (150683-30-0) → 7-chloro-2,3-dihydro-1H-benzo[b]azepine (1316312-24-9) + DM-4128 (1432725-24-0) + C11H14ClNO + methyl 2-methyl-4-((2-methylbenzoyl)amino)benzoate + (4-amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone + (4-amino-2-methylphenyl)(7-chloro-4-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methanone + 2-methyl-4-(2-methylbenzoylamino)benzoic acid (317374-08-6)

Guidance literature:

With hydrogenchloride; water; at 80 ℃; for 24h;

DOI:10.1039/c4ra16644b

upstream raw materials:

tolvaptan

methanol