2-amino-6-chloro-3-fluoropyridine

Base Information

• Chemical Name: 2-amino-6-chloro-3-fluoropyridine
• CAS No.: 1260672-14-7
• Molecular Formula: C₅H₄ClFN₂
• Molecular Weight: 146.552
• Mol file: 1260672-14-7.mol

Synonyms:

Chemical Property of 2-amino-6-chloro-3-fluoropyridine

Chemical Property:

• Boiling Point: 222.3±35.0 °C(Predicted)
• Density: 1.449±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

6-chloro-3-fluoropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-6-chloro-3-fluoropyridine

There total 1 articles about 2-amino-6-chloro-3-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

2,6-dichloro-3-fluoropyridine (52208-50-1) → 3-amino-2,6-dichloropyridine (62476-56-6) + 2-amino-6-chloro-3-fluoropyridine (1260672-14-7)

Guidance literature:

With ammonium hydroxide; In ethanol; at 150 - 157 ℃; for 16h; Yield given. Title compound not separated from byproducts; sealed tube;

DOI:10.1002/jhet.5570210309

Reference yield:

2-amino-6-chloro-3-fluoropyridine (1260672-14-7) → 5-(6-amino-3-chloro-5-fluoropyridin-2-yl)-2-chloro-N-(3-cyano-1-phenyl-1H-pyrazol-5-yl)benzamide

Guidance literature:

Multi-step reaction with 5 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 2 h / 100 °C

2: N-chloro-succinimide / acetonitrile / 16 h / 75 °C

3: triethylamine; dmap / dichloromethane / 16 h / 20 °C

4: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

5: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 16 h / 85 °C

With pyridine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; lithium hydroxide monohydrate; water; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

2-amino-6-chloro-3-fluoropyridine (1260672-14-7) → methyl 5-(6-((tert-butoxycarbonyl)amino)-3-chloro-5-fluoropyridin-2-yl)-2-chlorobenzoate

Guidance literature:

Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 2 h / 100 °C

2: N-chloro-succinimide / acetonitrile / 16 h / 75 °C

3: triethylamine; dmap / dichloromethane / 16 h / 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; acetonitrile;

upstream raw materials:

2,6-dichloro-3-fluoropyridine

Refernces