4-(N,N-dimethylamino)-3-methylbenzyl acetate

Base Information

• Chemical Name: 4-(N,N-dimethylamino)-3-methylbenzyl acetate
• CAS No.: 76259-11-5
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 76259-11-5.mol

Synonyms:

Chemical Property of 4-(N,N-dimethylamino)-3-methylbenzyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(N,N-dimethylamino)-3-methylbenzyl acetate

There total 3 articles about 4-(N,N-dimethylamino)-3-methylbenzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.5%

N,N,2,4-tetramethylaniline (769-53-9) + palladium diacetate (3375-31-3) → N,2,4-trimethylaniline (13021-13-1) + 4-(N,N-dimethylamino)-3-methylbenzyl acetate (76259-11-5) + N,N,2,4-tetramethyl-6-acetoxyaniline (76259-12-6)

Guidance literature:

In acetic acid; benzene; at 80 ℃; for 5h;

DOI:10.1246/cl.1980.1331

Reference yield:

N,N-dimethyl-o-toluidine (609-72-3) → 4-(N,N-dimethylamino)-3-methylbenzyl acetate (76259-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrochloric acid

2: diethyl ether; potassium carbonate

With hydrogenchloride; diethyl ether; potassium carbonate;

Reference yield:

4-dimethylamino-3-methyl-benzyl alcohol (773871-29-7) + acetyl chloride (75-36-5) → 4-(N,N-dimethylamino)-3-methylbenzyl acetate (76259-11-5)

Guidance literature:

With diethyl ether; potassium carbonate;

upstream raw materials:

4-dimethylamino-3-methyl-benzyl alcohol

acetyl chloride

N,N,2,4-tetramethylaniline

palladium diacetate

Refernces