Technology Process of 1-(5-bromo-3-chloropyridine-2-yl)ethane-1-on
There total 1 articles about 1-(5-bromo-3-chloropyridine-2-yl)ethane-1-on which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-3-chloro-pyridine-2-carbonitrile; methylmagnesium bromide;
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 2.5h;
With
hydrogenchloride;
In
tetrahydrofuran; diethyl ether;
at 5 - 20 ℃;
for 0.333333h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / Cooling with ice
1.2: 15 h / 20 °C / Cooling with ice
2.1: dimethyl sulfoxide / 6 h / 100 °C
3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 12 h / 50 °C
4.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / Cooling with ice
1.2: 15 h / 20 °C / Cooling with ice
2.1: dimethyl sulfoxide / 6 h / 100 °C
3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 12 h / 50 °C
4.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
5.1: hydrazine hydrate / ethanol / 1 h / 60 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; hydrazine hydrate; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
