Technology Process of 3,5,5',8-tetramethyl-8-azapsoralen triflate
There total 12 articles about 3,5,5',8-tetramethyl-8-azapsoralen triflate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1: 30 percent / sodium ethoxide / ethanol / 12 h / Heating
2: tetrahydrofuran / 21 h
3: 1) NaIO4 / 40percent water/dioxane, 1) 3.5 h, 0 deg C, 2) 15 h, reflux
4: 87 percent / silver carbonate / tetrahydrofuran / 5 h / Heating
5: 67 percent / diisobutylaluminum hydride / hexane; dioxane / 50 °C
6: 85 percent / Mg / tetrahydrofuran / 2 h / 50 °C
7: 87 percent / acetyl bromide / 1) RT, 1 h, 2) reflux, 3 h
8: 96 percent / CH2Cl2 / 3 h / Heating
With
sodium periodate; Acetyl bromide; sodium ethanolate; diisobutylaluminium hydride; magnesium; silver carbonate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane;
DOI:10.1021/jo00290a019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 74 percent / aq. ammonia / 120 h / Ambient temperature
2: 76 percent / trifluoroacetic acid / 6 h / Heating
3: 87 percent / silver carbonate / tetrahydrofuran / 5 h / Heating
4: 67 percent / diisobutylaluminum hydride / hexane; dioxane / 50 °C
5: 85 percent / Mg / tetrahydrofuran / 2 h / 50 °C
6: 87 percent / acetyl bromide / 1) RT, 1 h, 2) reflux, 3 h
7: 96 percent / CH2Cl2 / 3 h / Heating
With
ammonium hydroxide; Acetyl bromide; diisobutylaluminium hydride; magnesium; silver carbonate; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/jo00290a019
