4-(4-nitrophenoxy)picolinic acid

Base Information

• Chemical Name: 4-(4-nitrophenoxy)picolinic acid
• CAS No.: 1184827-15-3
• Molecular Formula: C₁₂H₈N₂O₅
• Molecular Weight: 260.206
• Mol file: 1184827-15-3.mol

Synonyms:

Chemical Property of 4-(4-nitrophenoxy)picolinic acid

Chemical Property:

• Boiling Point: 466.6±35.0 °C(Predicted)
• Density: 1.464±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Nitrophenoxy)pyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-nitrophenoxy)picolinic acid

There total 4 articles about 4-(4-nitrophenoxy)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

ethyl 4-(4-nitrophenoxy)picolinate → 4-(4-nitrophenoxy)picolinic acid (1184827-15-3)

Guidance literature:

With ethanol; sodium hydroxide; at 20 ℃; for 1h;

Reference yield:

4-chloro-pyridine-2-carbonyl chloride (53750-66-6) → 4-(4-nitrophenoxy)picolinic acid (1184827-15-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.33 h / Cooling with ice

1.2: 0.5 h / Cooling with ice

2.1: chlorobenzene / 4 h / 130 °C / UV-irradiation

3.1: ethanol; sodium hydroxide / 1 h / 20 °C

With ethanol; triethylamine; sodium hydroxide; In dichloromethane; chlorobenzene;

Reference yield:

2-Picolinic acid (98-98-6) → 4-(4-nitrophenoxy)picolinic acid (1184827-15-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 24 h / 85 °C

2.1: triethylamine / dichloromethane / 0.33 h / Cooling with ice

2.2: 0.5 h / Cooling with ice

3.1: chlorobenzene / 4 h / 130 °C / UV-irradiation

4.1: ethanol; sodium hydroxide / 1 h / 20 °C

With thionyl chloride; ethanol; triethylamine; sodium hydroxide; In dichloromethane; chlorobenzene;

upstream raw materials:

4-chloro-pyridine-2-carbonyl chloride

2-Picolinic acid

ethyl 4-chloropyridine-2-carboxylate