1-(difluoromethyl)pyrene

Base Information

• Chemical Name: 1-(difluoromethyl)pyrene
• CAS No.: 1186195-16-3
• Molecular Formula: C₁₇H₁₀F₂
• Molecular Weight: 252.263
• Mol file: 1186195-16-3.mol

Synonyms:

Chemical Property of 1-(difluoromethyl)pyrene

Chemical Property:

• Boiling Point: 396.8±27.0 °C(Predicted)
• Density: 1.328±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

1-(Difluoromethyl)pyrene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(difluoromethyl)pyrene

There total 3 articles about 1-(difluoromethyl)pyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-pyrenylboronic acid (164461-18-1) + 2,2‐difluoro‐2‐(triphenylphosphonio)acetate → 1-(difluoromethyl)pyrene (1186195-16-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-cyclopentadione; calcium hydroxide; In para-xylene; water; at 90 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02141

Reference yield: 69.0%

iododifluoromethane (1493-03-4) + (pyren-1-yl)magnesium bromide (138181-90-5) → 1-(difluoromethyl)pyrene (1186195-16-3)

Guidance literature:

With iron(III)-acetylacetonate; In tetrahydrofuran; at -20 - 20 ℃; for 0.5h; Glovebox; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.9b00585

Reference yield: 60.0%

→ 1-(difluoromethyl)pyrene (1186195-16-3)

Guidance literature:

With Tetrafluorophthalonitrile; tetramethylammonium fluoride; In acetonitrile; at 85 ℃; Glovebox; Inert atmosphere;

upstream raw materials:

1-pyrenylboronic acid

iododifluoromethane

(pyren-1-yl)magnesium bromide

Refernces

• 1、 Motohashi, Hirotaka,Kato, Miki,Mikami, Koichi. "Ligand-Less Iron-Catalyzed Aromatic Cross-Coupling Difluoromethylation of Grignard Reagents with Difluoroiodomethane". . p. 6483 - 6490. Retrieved 2019/05/16.