ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate

Base Information

• Chemical Name: ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate
• CAS No.: 102608-31-1
• Molecular Formula: C₇H₁₀F₃NO₄
• Molecular Weight: 229.156
• Mol file: 102608-31-1.mol

Synonyms:

Chemical Property of ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate

Chemical Property:

• Boiling Point: 240.2±50.0 °C(Predicted)
• PKA: 10.16±0.20(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)

Purity/Quality:

ETHYL 4,4,4-TRIFLUORO-3-HYDROXY-2-(METHOXYIMINO)BUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate

There total 3 articles about ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 4,4,4-trifluoro-2-methoxyimino-3-oxobutanoate (82874-80-4,119124-16-2) → ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate (102608-31-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1h; Ambient temperature;

DOI:10.1055/s-1985-31363

Reference yield:

ethyl 4,4,4-trifluoro-2-(hydroxyimino)-3-oxobutanoate (94609-23-1) → ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate (102608-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / 0.5 h / 25 - 30 °C

2: 94 percent / NaBH₄ / methanol / 1 h / Ambient temperature

With sodium tetrahydroborate; potassium carbonate; In methanol; acetone;

DOI:10.1055/s-1985-31363

Reference yield:

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 4,4,4-trifluoro-3-hydroxy-2-methoxyiminobutanoate (102608-31-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; H₂O

2: K₂CO₃ / acetone / 0.5 h / 25 - 30 °C

3: 94 percent / NaBH₄ / methanol / 1 h / Ambient temperature

With sodium tetrahydroborate; potassium carbonate; In methanol; water; acetic acid; acetone;

DOI:10.1055/s-1985-31363

upstream raw materials:

ethyl 4,4,4-trifluoro-2-methoxyimino-3-oxobutanoate

ethyl 4,4,4-trifluoro-2-(hydroxyimino)-3-oxobutanoate

ethyl 4,4,4-trifluoroacetoacetate

Refernces