94609-23-1Relevant academic research and scientific papers
IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS
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Page/Page column 22; 60, (2020/07/25)
The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.
New one-pot synthesis of 4-hydroxyimino-5-polyfluoroalkylpyrazol-3-ones, their structure and biological activity
Burgart, Yanina V.,Agafonova, Natalya A.,Shchegolkov, Evgeny V.,Maslova, Vera V.,Triandafilova, Galina A.,Solodnikov, Sergey Yu.,Krasnykh, Olga P.,Saloutin, Victor I.
, p. 52 - 59 (2019/02/25)
[Figure not available: see fulltext.] We propose different methods for the synthesis of 4-hydroxyimino-5-polyfluoroalkylpyrazol-3-ones. The simplest and most convenient procedure relies on sequential one-pot treatment of polyfluoroalkyl-3-oxoesters with hydrazine and sodium nitrite in acetic acid. It was established that 4-hydroxyimino-5-polyfluoroalkylpyrazol-3-ones exist in solid state and in solutions as mixtures of Z,Е-isomers of the hydroxyimine tautomer. The synthesized compounds were characterized with respect to in vivo analgesic activity and acute toxicity.
INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE
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Page/Page column 116, (2019/03/05)
The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed.
INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE
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Page/Page column 94, (2019/08/20)
The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia the treatment of cancer is disclosed. Formula (I)
METHOD FOR THE PREPARATION OF 3-(TRIFLUOROMETHYL)PYRAZINE-2-CARBOXYLIC ACID ESTERS
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Page/Page column 14; 16; 22; 26; 27, (2018/03/25)
The invention discloses a method for the preparation of 3-(trifluoromethyl)pyrazine-2-carboxylic acid esters starting from alkyl 4,4,4-trifluoro-2-(hydroxyimino)-3-oxobutanoates by reaction with ethylenediamine.
Short and Safe Synthesis of Ethyl 3-(Trifluoromethyl)pyrazine-2-carboxylate
Zaragoza, Florencio,Gantenbein, Annabelle
, p. 448 - 450 (2017/03/24)
The treatment of ethyl 2-hydroxyimino-4,4,4-trifluoro-3-oxobutanoate (3) with trialkyl phosphites, ethylenediamine, and an excess of a carboxylic acid in pyridine or picoline leads to the formation of an intermediate, which can be aromatized to a pyrazine by treatment with bromine or other oxidants. This synthesis can be performed either with the isolated oxime 3 or from ethyl 4,4,4-trifluoro-3-oxobutanoate (1) in a one-pot fashion, without any solvent change and without having to isolate any intermediates.
Pyrrolo [3,2-C] Pyridine-4-One 2-Indolinone Protein Kinase Inhibitors
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Page/Page column 99, (2010/02/16)
The present invention relates to pyrrolo[3,2-c]pyridine-4-one 2-indolinone compounds of Formula (I) and their pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8X, Y and have the meaning cited in the specification.
PYRROLO [3,2-C] PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS
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Page/Page column 169, (2010/11/28)
The present invention relates to pyrrolo[3,2-c]pyridine-4-one 2-indolinone compounds of Formula (I) and their pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8 X , Y and …. have the meaning cited in the specifica
