25361-54-0

Basic information

• Product Name: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride
• CAS NO: 25361-54-0
• Molecular Formula: C₂₀H₁₉NOP*Cl
• Molecular Weight: 355.7977
• Mol File: 25361-54-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride(25361-54-0)
• EPA Substance Registry System: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride(25361-54-0)

Safety Data

• Hazardous Substances Data: 25361-54-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2-amino-2-oxoethyl)(triphenyl)phosphonium chloride" is a phosphonium salt with a cation containing a phosphonium group attached to a 2-amino-2-oxoethyl group and three phenyl groups. The compound is commonly used as a reactant in organic synthesis and as a phase-transfer catalyst due to its ability to transfer the 2-amino-2-oxoethyl group between different phases. It has also been studied for its potential antimicrobial and antifungal properties. The compound's unique structure makes it a versatile and valuable reagent in various chemical reactions and biological research.

Upstream product

• 603-35-0 triphenylphosphine 
• 79-07-2 Chloroacetamide 

Downstream Products

• 119930-84-6 3-(triphenyl-λ⁵-phosphanylidene)piperidine-2,6-dione 
• 58498-57-0 6-tert-butylpyridin-2(1H)-one 
• 28811-77-0 1.3.5-Tris-(cyclohexylcarbonyl)-benzol 
• 1159814-04-6 6-cyclohexylpyridin-2(1H)-one 
• 292825-75-3 2,6-dicyclohexylpyridine 
• 403517-92-0 triphenyl(thiocarbamoylmethylene)phosphorane 
• 38821-11-3 2-(triphenylphosphoranylidene)acetamide 
• 1426942-96-2 (E)-3-(5-bromo-2-nitrophenyl)acrylamide 

Relevant articles and documents

COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION

The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.

A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics. Central to our strategy is the use of a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for terphenyl assembly. With the halogen/diazonium route and the halogen/triflate route, two strategies have successfully been established. The synthesis of core building blocks with aliphatic (Ala, Val, Leu, Ile), aromatic (Phe), polar (Cys, Lys), hydrophilic (Ser, Gln), and acidic (Glu) amino acid side chains are reported. Turn on: Teraryl-based α-helix mimetics can be effectively produced by sequential Suzuki coupling of a central core fragment featuring electronically differentiated leaving groups with aryl boronic pinacol esters (see scheme; dppf=1,1′-bis(diphenylphosphino) ferrocene, DME=dimethoxyethane, Pin=pinacol, Tf=trifluoromethanesulfonyl). With a set of only 2×18 building blocks, all permutations of α-helix mimetics can be produced. Copyright

Syntheses of highly functionalised 6-substituted pteridines.

Methods for the synthesis of polyfunctional 6-substituted pteridines from the corresponding 6-aldehydes are described. Alkene, ester, ketone, amide, cyano, oxime, bromo, methoxy and dihydroxy functional groups have all been introduced principally through