N-acetyl N'-methylpipecolinamide

Base Information

• Chemical Name: N-acetyl N'-methylpipecolinamide
• CAS No.: 133733-27-4
• Molecular Formula: C₉H₁₆N₂O₂
• Molecular Weight: 184.238
• Mol file: 133733-27-4.mol

Synonyms:

Chemical Property of N-acetyl N'-methylpipecolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl N'-methylpipecolinamide

There total 4 articles about N-acetyl N'-methylpipecolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylamine (74-89-5) → N-acetyl N'-methylpipecolinamide (133733-27-4,221690-21-7)

Guidance literature:

With methanol;

DOI:10.1021/ja01652a032

Reference yield:

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (98303-20-9) → N-acetyl N'-methylpipecolinamide (133733-27-4,221690-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / benzotriazol-1-yl-1,1,3,3-tetramethyluronium terafluoroborate, diisopropylethylamine / acetonitrile / 24 h / Ambient temperature

2: 1.) HCl, 2.) Et₃N / 1.) CH₂Cl₂, room temp., 1 h, 2.) CH₂Cl₂, reflux, overnight

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1021/jo982181h

Reference yield:

pipecolic Acid (4043-87-2,83680-83-5) → N-acetyl N'-methylpipecolinamide (133733-27-4,221690-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / aq. NaOH / dioxane / 48 h / Ambient temperature

2: 74 percent / benzotriazol-1-yl-1,1,3,3-tetramethyluronium terafluoroborate, diisopropylethylamine / acetonitrile / 24 h / Ambient temperature

3: 1.) HCl, 2.) Et₃N / 1.) CH₂Cl₂, room temp., 1 h, 2.) CH₂Cl₂, reflux, overnight

With hydrogenchloride; sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;

DOI:10.1021/jo982181h

upstream raw materials:

acetic anhydride

1-(tert-butoxycarbonyl)-N-methylpipecolinamide

methylamine

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid