METHYL (3R)-3-AMINO-3-(3-CHLOROPHENYL)PROPANOATE

Base Information

• Chemical Name: METHYL (3R)-3-AMINO-3-(3-CHLOROPHENYL)PROPANOATE
• CAS No.: 905991-90-4
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.664
• Mol file: 905991-90-4.mol

Synonyms:

Chemical Property of METHYL (3R)-3-AMINO-3-(3-CHLOROPHENYL)PROPANOATE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Benzenepropanoicacid,?-amino-3-chloro-,methylester,(?R)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL (3R)-3-AMINO-3-(3-CHLOROPHENYL)PROPANOATE

There total 8 articles about METHYL (3R)-3-AMINO-3-(3-CHLOROPHENYL)PROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + 3-amino-3-(3-chloro-phenyl)-propionic acid (68208-21-9) → 3-amino-3-(3-chlorophenyl)propionic acid methyl ester (277745-44-5,309757-83-3,905991-90-4)

Guidance literature:

methanol; 3-amino-3-(3-chloro-phenyl)-propionic acid; With thionyl chloride; at -10 - 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate; pH=7;

Reference yield: 84.0%

(R)-S-tert-butyl 3-(3-chlorophenyl)-3-[(2-thienylsulfonyl)amino]propanethioate (905991-50-6) + methanol (67-56-1) → (R)-methyl 3-amino-3-(3-chlorophenyl)propanoate (309757-83-3,905991-90-4)

Guidance literature:

With magnesium; at 20 ℃; for 5h;

DOI:10.1021/ol060866v

Reference yield: 56.0%

(S)-3-(3-Chloro-phenyl)-3-[(R)-1-(4-methoxy-phenyl)-ethylamino]-propionic acid methyl ester; hydrochloride → methyl (S)-3-(3-chlorophenyl)-3-aminopropanoate (309757-83-3,905991-90-4)

Guidance literature:

With ammonium cerium(IV) nitrate; sodium hydrogencarbonate; In methanol; at 20 ℃;

upstream raw materials:

(R)-S-tert-butyl 3-(3-chlorophenyl)-3-[(2-thienylsulfonyl)amino]propanethioate

methanol

N-(3-chlorophenyl)methylidene 2-thiophenesulfonamide

m-Chlorobenzaldehyde

Refernces

• 1、 Gonzalez, Alvaro Salvador,Arrayas, Ramon Gomez,Carretero, Juan C.. "Copper(I)-fesulphos Lewis acid catalysts for enantioselective Mannich-type reaction of N-sulfonyl imines". . p. 2977 - 2980. Retrieved 2007/10/03.
• 2、 Bull, Steven D.,Davies, Stephen G.,Delgado-Ballester, Santiago,Kelly, Peter M.,Kotchie, Luke J.,Gianotti, Massimo,Laderas, Mario,Smith, Andrew D.. "Asymmetric synthesis of β-haloaryl β-amino acid derivatives". . p. 3112 - 3121. Retrieved 2007/10/03.