Hydroxy-PEG6-CH2CO2tBu

Base Information

• Chemical Name: Hydroxy-PEG6-CH2CO2tBu
• CAS No.: 297162-47-1
• Molecular Formula: C₁₈H₃₆O₉
• Molecular Weight: 396.478
• Hs Code.: 2942000090
• Mol file: 297162-47-1.mol

Synonyms:

Chemical Property of Hydroxy-PEG6-CH2CO2tBu

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hydroxy-PEG6-CH2CO2tBu 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Hydroxy-PEG6-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of Hydroxy-PEG6-CH2CO2tBu

There total 8 articles about Hydroxy-PEG6-CH2CO2tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl 1-phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-oate (185990-09-4) → tert-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosanoate (297162-47-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃;

Reference yield: 41.0%

pentaethylene glycol (2615-15-8) + bromoacetic acid tert-butyl ester (5292-43-3) → tert-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosanoate (297162-47-1)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 5 ℃; for 2h;

DOI:10.1055/s-0035-1560520

Reference yield:

pentaethylene glycol (2615-15-8) + t-butyl diazoacetate (35059-50-8) → 3,6,9,12,15,18,21-heptaoxatricosane-1,23-dioic acid di-tert-butyl ester (211746-80-4) + tert-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosanoate (297162-47-1)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; for 1.25h; Title compound not separated from byproducts.;

DOI:10.1002/chem.200204304

upstream raw materials:

pentaethylene glycol

t-butyl diazoacetate

bromoacetic acid tert-butyl ester

1-phenyl-2,5,8,11-tetraoxatridecan-13-ol

Refernces

• 1、 -. "TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT". . . Retrieved 2021/12/23.
• 2、 De Feijter, Isja,Goor, Olga J. G. M.,Hendrikse, Simone I. S.,Comellas-Aragonès, Marta,S?ntjens, Serge H. M.,Zaccaria, Sabrina,Fransen, Peter P. K. H.,Peeters, Joris W.,Milroy, Lech-Gustav,Dankers, Patricia Y. W.. "Solid-Phase-Based Synthesis of Ureidopyrimidinone-Peptide Conjugates for Supramolecular Biomaterials". supporting information. p. 2707 - 2713. Retrieved 2015/11/27.