1-Fluoro-4-methoxy-2-methyl-5-nitrobenzene

Base Information

• Chemical Name: 1-Fluoro-4-methoxy-2-methyl-5-nitrobenzene
• CAS No.: 182880-71-3
• Molecular Formula: C₈H₈FNO₃
• Molecular Weight: 185.155
• Hs Code.: 2909309090
• European Community (EC) Number: 816-582-1
• Mol file: 182880-71-3.mol

Synonyms:1-fluoro-4-methoxy-2-methyl-5-nitrobenzene;182880-71-3;4-Fluoro-5-methyl-2-nitroanisole;MFCD18157656;SCHEMBL19927661;AKOS015853361;LE-0017;SY275407;CS-0448907

Chemical Property of 1-Fluoro-4-methoxy-2-methyl-5-nitrobenzene

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 185.04882128
• Heavy Atom Count: 13
• Complexity: 194

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-5-methyl-2-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1F)[N+](=O)[O-])OC

Technology Process of 1-Fluoro-4-methoxy-2-methyl-5-nitrobenzene

There total 5 articles about 1-Fluoro-4-methoxy-2-methyl-5-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methanol (67-56-1) + 1,4-difluoro-2-methyl-5-nitrobenzene (141412-60-4) → 1-fluoro-4-methoxy-2-methyl-5-nitrobenzene (182880-71-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 60 ℃; for 12h;

Reference yield:

4-fluoro-3-methylanisol (2338-54-7) → 1-fluoro-4-methoxy-2-methyl-5-nitrobenzene (182880-71-3) + 1-Fluoro-4-methoxy-2-methyl-3-nitro-benzene + 4-fluoro-3-methyl-2,6-dinitrophenol + 2-Fluoro-5-methoxy-1-methyl-3-trinitromethyl-benzene

Guidance literature:

With tetranitromethane; In acetonitrile; at 20 ℃; for 4h; Further byproducts given; Irradiation;

Reference yield:

4-fluoro-3-methylanisol (2338-54-7) → 4-fluoro-5-methyl-2-nitrophenol (182880-62-2) + 1-fluoro-4-methoxy-2-methyl-5-nitrobenzene (182880-71-3) + 1-Fluoro-4-methoxy-2-methyl-3-nitro-benzene + 1-Fluoro-4-methoxy-2-methyl-5-trinitromethyl-benzene

Guidance literature:

With tetranitromethane; In acetonitrile; at -20 ℃; for 6h; Further byproducts given; Irradiation;

upstream raw materials:

tetranitromethane

4-fluoro-3-methylanisol

methanol

1,4-difluoro-2-methyl-5-nitrobenzene