1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine

Base Information

• Chemical Name: 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine
• CAS No.: 159701-21-0
• Molecular Formula: C₄₂H₈₀NO₈P
• Molecular Weight: 758.073
• Mol file: 159701-21-0.mol

Synonyms:

Chemical Property of 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states.

Technology Process of 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine

There total 21 articles about 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

linoleic acid (60-33-3,116745-32-5,26085-09-6,64080-88-2,7049-66-3,949900-18-9,60476-23-5,6144-28-1,67922-65-0,89718-18-3) + 1-palmitoyllysophosphatidylcholine (17364-18-0) → 1-palmitoyl-2-lineleoylphosphatidylcholine (6931-84-6,159701-21-0)

Guidance literature:

With dmap; 2,4,6-trichlorobenzoyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 13h;

DOI:10.1055/s-2005-871973

Reference yield: 77.0%

linoleic acid (60-33-3,116745-32-5,26085-09-6,64080-88-2,7049-66-3,949900-18-9,60476-23-5,6144-28-1,67922-65-0,89718-18-3) + 1-palmitoyl-sn-glycero-3-phosphocholine (17364-16-8,17364-17-9,17364-18-0,14863-27-5) → lecithin (6931-84-6,70094-88-1,128114-92-1,17708-90-6,159701-21-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/anie.200500534

Reference yield: 58.9%

2-chloroethyl phosphorodichloridate (1455-05-6) + 1-O-palmitoyl-2-arachidonoyl-glycerol (65886-78-4) + trimethylamine (75-50-3) → lecithin (6931-84-6,70094-88-1,128114-92-1,17708-90-6,159701-21-0)

Guidance literature:

2-chloroethyl phosphorodichloridate; 1-O-palmitoyl-2-arachidonoyl-glycerol; With triethylamine; In dichloromethane;

With water; triethylamine; In dichloromethane;

trimethylamine; In ethanol; at 70 - 80 ℃; for 72h;

DOI:10.1248/cpb.47.1659

upstream raw materials:

linoleic acid

1-palmitoyllysophosphatidylcholine

choline tosylate

glycerolcholine phosphate

Downstream raw materials:

1-hexadecanoyl-2-(9-carboxynonanoyl)glycerophosphocholine

Refernces

• 1、 Ayanoglu, Eser,Wegmann, Annemarie,Pilet, Olivier,Marbury, G. Dean,Hass, J. Ronald,Djerassi, Carl. "MASS SPECTROMETRY OF PHOSPHOLIPIDS. SOME APPLICATIONS OF DESORPTION CHEMICAL IONIZATION AND FAST ATOM BOMBARDMENT". . p. 5246 - 5251. Retrieved 1984.
• 2、 -. "NOVEL FORMULATION OF DEHYDRATED LIPID VESICLES FOR CONTROLLED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT VIA INHALATION". . . Retrieved 2009/03/07.