4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid

Base Information

• Chemical Name: 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid
• CAS No.: 2055023-26-0
• Molecular Formula: C₂₄H₄₆O₁₄
• Molecular Weight: 558.621
• Mol file: 2055023-26-0.mol

Synonyms:

Chemical Property of 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid

Chemical Property:

• Boiling Point: 657.7±55.0 °C(Predicted)
• Density: 1.169±0.06 g/cm3(Predicted)

Purity/Quality:

99.3% ^*data from raw suppliers

α,ω-dipropionicacidnonaethyleneglycol min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bis-PEG10-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid

There total 3 articles about 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nonaethylene glycol (3386-18-3) → 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid (2055023-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / benzene / 1 h / Ambient temperature

2: 12M hydrochloric acid / 0.08 h / Heating

With hydrogenchloride; potassium hydroxide; In benzene;

DOI:10.1246/bcsj.61.2443

Reference yield:

1,20-dichloro-3,6,9,12,15,18-hexaoxatetradecane (56930-39-3,27252-69-3) → 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid (2055023-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / 48 h / 80 °C

2: potassium hydroxide / benzene / 1 h / Ambient temperature

3: 12M hydrochloric acid / 0.08 h / Heating

With hydrogenchloride; potassium hydroxide; potassium hydroxide; In benzene;

DOI:10.1246/bcsj.61.2443

Reference yield:

3-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-Cyano-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionitrile → 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid (2055023-26-0)

Guidance literature:

With hydrogenchloride; for 0.0833333h; Heating;

DOI:10.1246/bcsj.61.2443

upstream raw materials:

nonaethylene glycol

1,20-dichloro-3,6,9,12,15,18-hexaoxatetradecane