3386-18-3

Basic information

• Product Name: Nonaethylene glycol
• Synonyms: Nonaethylene glyco;NONAETHYLENE GLYCOL;3,6,9,12,15,18,21,24-octaoxahexacosane-1,26-diol;peg-9,polyoxyethylene(9),polyethyleneglycol450;2,2'-[1,2-Ethanediylbis[oxy(2,1-ethanediyl)oxy(2,1-ethanediyl)oxy(2,1-ethanediyl)oxy]]bis(ethanol);HO-PEG9-OH;PEG-9;2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• CAS NO: 3386-18-3
• Molecular Formula: C₁₈H₃₈O₁₀
• Molecular Weight: 414.49
• EINECS: 222-206-1
• Product Categories: Ethylene Glycols;Ethylene Glycols & Monofunctional Ethylene Glycols
• Mol File: 3386-18-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 24.0-25.2 °C
• Boiling Point: 506.2°Cat760mmHg
• Flash Point: 26 °C
• Appearance: /
• Density: 1.115g/cm³
• Refractive Index: 1.46
• Storage Temp.: 2-8°C
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: Nonaethylene glycol(CAS DataBase Reference)
• NIST Chemistry Reference: Nonaethylene glycol(3386-18-3)
• EPA Substance Registry System: Nonaethylene glycol(3386-18-3)

Safety Data

• RTECS: RA5400000
• Hazardous Substances Data: 3386-18-3(Hazardous Substances Data)

Usage

Description

Nonaethylene glycol is a polymer consisting of ethylene glycol repeating units and terminal hydroxyl groups. The ethylene glycol units have high water solubility properties. The hydroxyl groups can react in order to further derivatize the compound.

Uses

HO-PEG9-OH is used as a reactant in the selective inhibition of human brain tumor cells through quantum-dot-based siRNA delivery.

InChI:InChI=1/C2H6O2.9C2H4/c3-1-2-4;9*1-2/h3-4H,1-2H2;9*1-2H2

Upstream product

• 56930-39-3 1,20-dichloro-3,6,9,12,15,18-hexaoxatetradecane 
• 107-21-1 ethylene glycol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 27712-99-8 1,3,6,9,2λ⁴-Tetraoxathia-2-cycloundecanon 
• 60389-48-2 C₂₄H₃₄O₆ 
• 105891-51-8 (2-{2-[2-(2-Chloro-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene 
• 57671-28-0 2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 112-60-7 Tetraethylene glycol 
• 133699-09-9 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol 
• 80322-82-3 triethyleneglycol dimesylate 
• 669556-37-0 17-(tetrahydro-2H-pyran-2-yloxy)-3,6,9,12,15-pentaoxaheptadecyl 4-methylbenzenesulfonate 
• 60221-37-6 8-(1H-tetrahydropyran-2-yloxy)-3n₆³-dioxaoctan-1-ol 

Downstream Products

• 4445-03-8 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-heptadecaoxa-tripentacontane-1,53-diol 
• 28780-45-2 α-hydro, ω-hydroxyheptacosa(oxyethylene) 
• 29928-00-5 hexatriaconta(ethylene glycol) 
• 361543-07-9 1,2-bis-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethane 
• 77963-47-4 o-hydroxyphenyl 3,6,9,12,15,18,21,24-octaoxa-26-bromohexacosyl ether 

Relevant articles and documents

Synthesis of oligo(ethylene glycol) toward 44-mer

A synthetic method for oligo(ethylene glycol) toward 44-mer (FW = 1956.35) is described. Reiteration of Williamson's ether synthesis and hydrogenation to remove protecting benzyl group affords desired oligo(ethylene glycol) toward 44-mer in moderate yields. The advantages in this method are use of commercially easily available materials as starting materials and procedures avoiding difficulty in purification of the products as much as possible.

Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains

A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2-CH2)nY (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.