N-formyl-3,4-methylenedioxyamphetamine

Base Information

• Chemical Name: N-formyl-3,4-methylenedioxyamphetamine
• CAS No.: 67669-00-5
• Molecular Formula: C11H13 N O3
• Molecular Weight: 207.229
• Mol file: 67669-00-5.mol

Synonyms:Formamide,N-[b-methyl-3,4-(methylenedioxy)phenethyl]-(7CI)

Chemical Property of N-formyl-3,4-methylenedioxyamphetamine

Chemical Property:

• Vapor Pressure: 6.87E-07mmHg at 25°C
• Boiling Point: 408.7°C at 760 mmHg
• Flash Point: 201°C
• PSA: 51.05000
• Density: 1.198g/cm³
• LogP: 1.93260

Purity/Quality:

99% ^*data from raw suppliers

(+/-)-N-FORMYL-3,4-METHYLENEDIOXYAMPHETAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-formyl-3,4-methylenedioxyamphetamine

There total 2 articles about N-formyl-3,4-methylenedioxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,4-methylenedioxyamphetamine (4764-17-4) + formyl acetic anhydride (2258-42-6) → N-(2-benzo[1,3]dioxol-5-yl-1-methylethyl)formamide (67669-00-5)

Guidance literature:

at 50 ℃; for 0.5h;

Reference yield:

3,4-methylenedioxyamphetamine (4764-17-4) + Methyl formate (107-31-3) → N-(2-benzo[1,3]dioxol-5-yl-1-methylethyl)formamide (67669-00-5)

Guidance literature:

Heating;

DOI:10.1124/jpet.105.084426

Reference yield:

N-(2-benzo[1,3]dioxol-5-yl-1-methylethyl)formamide (67669-00-5) → 7-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline hydrochloride (58260-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / phosphorous oxychloride / acetonitrile / 1 h / Heating

2: 70.3 percent / 1M BH₃; HCl gas / tetrahydrofuran; diethyl ether

With hydrogenchloride; borane; trichlorophosphate; In tetrahydrofuran; diethyl ether; acetonitrile; 1: Dehydration / 2: Hydrogenation;

upstream raw materials:

3,4-methylenedioxyamphetamine

formyl acetic anhydride

Methyl formate

Downstream raw materials:

7-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline hydrochloride

Refernces

• 1、 Malmusi, Luca,Dukat, Malgorzata,Young, Richard,Teitler, Milt,Darmani, Nissar A.,Ahmad, Bashir,Smith, Carol,Glennon, Richard A.. "1,2,3,4-Tetrahydroisoquinoline and related analogs of the phenylalkylamine designer drug MDMA". . p. 412 - 426. Retrieved 2007/10/03.