ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

Base Information

Chemical Name:ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate
CAS No.:2101958-02-3
Molecular Formula:C₂₅H₃₂F₃N₅O₄
Molecular Weight:523.555
Hs Code.:

Synonyms:

Suppliers and Price of ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
SquarunkinA >98%
1 g
$ 1800.00

DC Chemicals
SquarunkinA >98%
250 mg
$ 950.00

Biosynth Carbosynth
Squarunkin A NEW
50 mg
$ 332.50

Biosynth Carbosynth
Squarunkin A NEW
10 mg
$ 95.00

Axon Medchem
SquarunkinA 99%
2 x 50 mg
$ 836.00

Axon Medchem
SquarunkinA 99%
10 mg
$ 137.50

AK Scientific
SquarunkinA
10mg
$ 178.00

Total 9 raw suppliers

Chemical Property of ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

SquarunkinA >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

There total 3 articles about ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 933006-05-4
ethyl 4-((2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

: 27144-85-0
2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethan-1-amine

: 2101958-02-3
ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

Guidance literature:: With triethylamine; In ethanol; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201701905

Reference yield:

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 2101958-02-3
ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 14 h / Reflux; Inert atmosphere

2: hydrazine / ethanol / 2 h / Reflux

3: triethylamine / ethanol / 12 h / 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; hydrazine; In ethanol; acetonitrile;
DOI:10.1002/anie.201701905

Reference yield:

: 2-(2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-isoindoline-1,3-dione

: 2101958-02-3
ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / ethanol / 2 h / Reflux

2: triethylamine / ethanol / 12 h / 20 °C / Inert atmosphere

With triethylamine; hydrazine; In ethanol;
DOI:10.1002/anie.201701905