2-aminomethyl-4-isopropylpyridine

Base Information

• Chemical Name: 2-aminomethyl-4-isopropylpyridine
• CAS No.: 900800-27-3
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.224
• Mol file: 900800-27-3.mol

Synonyms:

Chemical Property of 2-aminomethyl-4-isopropylpyridine

Chemical Property:

• Boiling Point: 242.8±25.0 °C(Predicted)
• Density: 0.983±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

(4-Isopropylpyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-aminomethyl-4-isopropylpyridine

There total 3 articles about 2-aminomethyl-4-isopropylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-cyano-4-isopropylpyridine (676136-14-4) → 2-aminomethyl-4-isopropylpyridine (900800-27-3)

Guidance literature:

6-cyano-4-isopropylpyridine; With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; water; at 20 ℃; under 3800.26 Torr; Autoclave;

With potassium carbonate; In water;

Reference yield:

4-s-propylpyridine (696-30-0) → 2-aminomethyl-4-isopropylpyridine (900800-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / 20 °C / Inert atmosphere; Cooling with ice

2: N,N-Dimethylcarbamoyl chloride / dichloromethane / 20 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogenchloride; hydrogen / water; methanol / 20 °C / 3800.26 Torr / Autoclave

With hydrogenchloride; palladium on activated charcoal; hydrogen; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In methanol; dichloromethane; water;

Reference yield:

4-isopropylpyridine 1-oxide (22581-87-9) → 2-aminomethyl-4-isopropylpyridine (900800-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-Dimethylcarbamoyl chloride / dichloromethane / 20 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogenchloride; hydrogen / water; methanol / 20 °C / 3800.26 Torr / Autoclave

With hydrogenchloride; palladium on activated charcoal; hydrogen; N,N-Dimethylcarbamoyl chloride; In methanol; dichloromethane; water;

upstream raw materials:

6-cyano-4-isopropylpyridine

4-s-propylpyridine

4-isopropylpyridine 1-oxide

Refernces

• 1、 -. "(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING". Page/Page column 68. . Retrieved 2009/05/29.