22581-87-9

Upstream product

• 696-30-0 4-s-propylpyridine 

Downstream Products

• 676136-14-4 6-cyano-4-isopropylpyridine 
• 83282-36-4 4-isopropyl-pyridine-2-carboxylic acid 
• 756464-00-3 4-isopropyl-piperidine-2-carboxylic acid 
• 261777-45-1 (2S,4S)-trans-4-(2-propyl)-2-piperidinecarboxylic acid methyl ester 
• 261777-42-8 (2S,4S)-trans-4-(2-propyl)-1,2-piperidinedicarboxylic acid 2-methyl 1-(phenylmethyl) diester 
• 261777-39-3 (2R,4S)-cis-4-(2-propyl)-1,2-piperidinedicarboxylic acid 2-methyl 1-(phenylmethyl) diester 
• 261777-33-7 (2R,4S)-cis-4-(2-propyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester 
• 900800-27-3 2-aminomethyl-4-isopropylpyridine 

Relevant academic research and scientific papers

PRODUCTION METHOD OF OPTICALLY ACTIVE SECONDARY ALCOHOL

PROBLEM TO BE SOLVED: To provide a chemical catalytic method allowing efficient production of a corresponding optically active secondary alcohol from an aromatic ketone having a substituent at each of two β-positions in an aromatic ring to the carbonyl site, so that both enantiomers can be separately made. SOLUTION: A production method of optically active secondary alcohol is characterized by reacting a ketone compound such as acetophenone derivatives with hydrogen in the presence of a ruthenium complex catalyst having an optically active diphosphine ligand. COPYRIGHT: (C)2015,JPO&INPIT

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)

Macrocyclic Compounds Useful as Bace Inhibitors

The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

LINCOMYCIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Synthesis of chiral nonracemic 4-trans-substituted pipecolic acid derivatives

The syntheses and resolutions of enantiomerically enriched 4-phenyl, 4- tert-butyl, and 4-isopropyl pipecolic acids are described. Optically active diastereomers were prepared by diastereomeric salt formation with the chiral base, L-tyrosine hydrazide, to

Reactivity of perfluoro-(cis-2,3-dialkyloxaziridines) with heteroaromatic nitrogen compounds

Pyridine N-oxides 3 are exclusively formed under particularly mild conditions when perfluorinated dialkyloxaziridines 1 are reacted with pyridine derivatives 2 bearing a substituent at the 2-position. Starting from pyridines substituted at the 3- and 4-positions, the previously unreported N-perfluoroacylpyridiniumaminides 4 are also produced and isolated as solid, stable compounds. Bis(pyridinium-N-aminides) 9, which have been prepared starting from bis-pyridine substrates and pyridazine and quinoxaline starting materials, also show the same reactivity. This behaviour reveals how oxaziridines 1 can work as both animating and oxygenating agents.