ethyl [10-(4-chlorophenyl)-4-oxo-4,7,8,9-tetrahydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-3-yl]acetate

Base Information

Chemical Name:ethyl [10-(4-chlorophenyl)-4-oxo-4,7,8,9-tetrahydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-3-yl]acetate
CAS No.:499142-34-6
Molecular Formula:C₂₁H₁₇ClN₄O₃S
Molecular Weight:440.91
Hs Code.:
Mol file:499142-34-6.mol

Synonyms:

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Chemical Property of ethyl [10-(4-chlorophenyl)-4-oxo-4,7,8,9-tetrahydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-3-yl]acetate

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Technology Process of ethyl [10-(4-chlorophenyl)-4-oxo-4,7,8,9-tetrahydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-3-yl]acetate

There total 4 articles about ethyl [10-(4-chlorophenyl)-4-oxo-4,7,8,9-tetrahydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 906375-98-2
4-(4-chloro-phenyl)-2,3-dihydro-1H,7H-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-8-one

: 105-39-5
chloroacetic acid ethyl ester

: 499142-34-6
[4-(4-chloro-phenyl)-8-oxo-1,2,3,8-tetrahydro-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-7-yl]-acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;
DOI:10.1002/jccs.200500136

Reference yield:

: 83236-50-4
4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione

: 499142-34-6
[4-(4-chloro-phenyl)-8-oxo-1,2,3,8-tetrahydro-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-7-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

2: 91 percent / sodium ethanolate / ethanol / 0.08 h / Heating

3: 80 percent / sodium nitrite; acetic acid; H₂SO₄ / H₂O / 0.08 h / 0 °C

4: 73 percent / potassium carbonate / dimethylformamide / 2 h / 80 °C

With sulfuric acid; sodium ethanolate; sodium acetate; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; 2: Thorpe-Ziegler cyclisation;
DOI:10.1002/jccs.200500136

Reference yield:

: 536720-22-6
2-carbamoylmethylsulfanyl-4-(4-chlorophenyl)-6,7-dihydro-5H-[1]pyrindine-3-carbonitrile

: 499142-34-6
[4-(4-chloro-phenyl)-8-oxo-1,2,3,8-tetrahydro-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-7-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / sodium ethanolate / ethanol / 0.08 h / Heating

2: 80 percent / sodium nitrite; acetic acid; H₂SO₄ / H₂O / 0.08 h / 0 °C

3: 73 percent / potassium carbonate / dimethylformamide / 2 h / 80 °C

With sulfuric acid; sodium ethanolate; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; 1: Thorpe-Ziegler cyclisation;
DOI:10.1002/jccs.200500136