C₁₅H₁₈F₂N₂O₃

Base Information

• Chemical Name: C₁₅H₁₈F₂N₂O₃
• CAS No.: 1488407-59-5
• Molecular Formula: C₁₅H₁₈F₂N₂O₃
• Molecular Weight: 312.316
• Mol file: 1488407-59-5.mol

Synonyms:

Chemical Property of C₁₅H₁₈F₂N₂O₃

Chemical Property:

• Density: 1.27±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((3-(3,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₈F₂N₂O₃

There total 3 articles about C₁₅H₁₈F₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4 difluorobenzaldehyde (34036-07-2) → C15H18F2N2O3 (1488407-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 6 h / 0 - 20 °C / Inert atmosphere

2: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / Inert atmosphere

With N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm401274b

Reference yield:

3,4-difluoro-benzaldehyde oxime (238743-29-8) → C15H18F2N2O3 (1488407-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / Inert atmosphere

With N-chloro-succinimide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm401274b

Reference yield:

N-tert-butoxycarbonylprop-2-en-1-amine (78888-18-3) + 3,4-difluoro-N-hydroxybenzimidoyl chloride (238743-30-1) → C15H18F2N2O3 (1488407-59-5)

Guidance literature:

With triethylamine; Inert atmosphere;

DOI:10.1021/jm401274b

upstream raw materials:

3,4 difluorobenzaldehyde

N-tert-butoxycarbonylprop-2-en-1-amine

3,4-difluoro-N-hydroxybenzimidoyl chloride

3,4-difluoro-benzaldehyde oxime