4-Methoxybenzofuran

Base Information

• Chemical Name: 4-Methoxybenzofuran
• CAS No.: 18014-96-5
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.161
• DSSTox Substance ID: DTXSID401315664
• Nikkaji Number: J3.284.632G
• Mol file: 18014-96-5.mol

Synonyms:4-Methoxybenzofuran;18014-96-5;4-methoxybenzo(b)furan;SCHEMBL827270;NWCMFNIMUUMBGZ-UHFFFAOYSA-N;DTXSID401315664

Chemical Property of 4-Methoxybenzofuran

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.052429494
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

4-methoxy-Benzofuran 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC2=C1C=CO2

Technology Process of 4-Methoxybenzofuran

There total 13 articles about 4-Methoxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxybenzofuran (480-97-7) + methyl iodide (74-88-4) → 4-methoxybenzofuran (18014-96-5)

Guidance literature:

With sodium hydride; In mineral oil;

DOI:10.1248/cpb.c12-00872

Reference yield:

1-(2,2-diethoxyethoxy)-3-methoxybenzene (108639-46-9) → 6-methoxybenzofuran (50551-63-8) + 4-methoxybenzofuran (18014-96-5)

Guidance literature:

With tin-exchanged H-b zeolite (Sn-b); for 0.5h; Overall yield = 87 %; Reflux;

DOI:10.1016/j.tet.2015.05.029

Reference yield:

O-methylresorcine (150-19-6) → 4-methoxybenzofuran (18014-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 24 h / Reflux

2: polyphosphoric acid / toluene / 12 h / Reflux

With sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.orglett.6b02857

upstream raw materials:

4-hydroxybenzofuran

dimethyl sulfate

(2-formyl-3-methoxy-phenoxy)-acetic acid

acetic anhydride