Benzofuran-4-ol

Base Information

• Chemical Name: Benzofuran-4-ol
• CAS No.: 480-97-7
• Molecular Formula: C8H6O2
• Molecular Weight: 134.134
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID20469337
• Nikkaji Number: J13.186E
• Wikidata: Q72445527
• Mol file: 480-97-7.mol

Synonyms:Benzofuran-4-ol;480-97-7;1-benzofuran-4-ol;4-Benzofuranol;4-Hydroxybenzofuran;1-benzouran-4-ol;4-hydroxy-benzofuran;SCHEMBL275378;DTXSID20469337;CFBCZETZIPZOGW-UHFFFAOYSA-N;CHEBI:189806;MFCD09754184;AKOS006328168;MB07641;TS-01729;AM20040545;CS-0072152;FT-0689575;EN300-102726;A846790;F2147-8694

Chemical Property of Benzofuran-4-ol

Chemical Property:

• Melting Point: 56-58℃
• Boiling Point: 108.102 °C at 760 mmHg
• PKA: 9.04±0.40(Predicted)
• Flash Point: 19.18 °C
• PSA: 33.37000
• Density: 1.28 g/cm³
• LogP: 2.13840
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 134.036779430
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

97% ^*data from raw suppliers

benzofuran-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C2C=COC2=C1)O
• Uses: Benzofuran-4-ol is a useful reserach chemical used in the preparation of 4- and 5-hydroxybenzofurans and their amino derivatives.

Technology Process of Benzofuran-4-ol

There total 13 articles about Benzofuran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-carboxy-4-hydroxybenzo-(b)-furan (112678-09-8) → 4-hydroxybenzofuran (480-97-7)

Guidance literature:

With copper; In quinoline; at 230 ℃; for 5h;

Reference yield: 60.0%

4-oxo-4,5,6,7-tetrahydrobenzofuran (16806-93-2) → 4-hydroxybenzofuran (480-97-7)

Guidance literature:

With 1-dodecene; palladium on activated charcoal; In decalin; for 24h; Reflux; Inert atmosphere;

DOI:10.1021/jo300021a

Reference yield:

4-hydroxybenzofuran-2-carboxylic acid (113511-42-5) → 4-hydroxybenzofuran (480-97-7)

Guidance literature:

With quinoline; copper; Heating;

DOI:10.1248/cpb.c12-00872

upstream raw materials:

furfural

acetic anhydride

sodium succinate

karanjic acid

Downstream raw materials:

4-methoxybenzofuran

4-hydroxy-2,3-dihydrobenzofuran

4-hydroxybenzofuran-5-carboxaldehyde

4-aminobenzofuran