452-15-3

Basic information

• Product Name: N-(3-fluoro-4-Methoxyphenyl)acetaMide
• Synonyms: N-(3-fluoro-4-Methoxyphenyl)acetaMide
• CAS NO: 452-15-3
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.1796032
• Mol File: 452-15-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 112-112.5 °C
• Boiling Point: 341.245°C at 760 mmHg
• Flash Point: 160.18°C
• Appearance: /
• Density: 1.215g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.539
• PKA: 13.74±0.70(Predicted)
• CAS DataBase Reference: N-(3-fluoro-4-Methoxyphenyl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoro-4-Methoxyphenyl)acetaMide(452-15-3)
• EPA Substance Registry System: N-(3-fluoro-4-Methoxyphenyl)acetaMide(452-15-3)

Safety Data

• Hazardous Substances Data: 452-15-3(Hazardous Substances Data)

Usage

General Description

N-(3-fluoro-4-Methoxyphenyl)acetaMide, also known as 3-fluoro-4-methoxyacetanilide, is an organic compound with the molecular formula C9H10FNO2. It is a derivative of acetanilide and is commonly used as an intermediate in the synthesis of pharmaceutical drugs. This chemical is a white to off-white solid that is sparingly soluble in water but soluble in organic solvents. It is utilized in the preparation of various pharmaceuticals, including analgesic and anti-inflammatory drugs. The fluoro and methoxy substituents in the molecule contribute to its biological activity and pharmacokinetics, making it a valuable building block in medicinal chemistry. Overall, N-(3-fluoro-4-Methoxyphenyl)acetaMide plays a crucial role in the pharmaceutical industry as a key intermediate for the synthesis of various therapeutic agents.

InChI:InChI=1/C9H10FNO2/c1-6(12)11-7-3-4-9(13-2)8(10)5-7/h3-5H,1-2H3,(H,11,12)

Upstream product

• 366-99-4 3-fluoro-4-methoxyaniline 
• 455-93-6 2-fluoro-1-methoxy-4-nitrobenzene 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 108-24-7 acetic anhydride 

Downstream Products

• 251902-52-0 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde 
• 446-20-8 5-fluoro-4-methoxy-2-nitroaniline 
• 2045-39-8 N-(3-fluoro-4-hydroxy-phenyl)acetamide 
• 448-26-0 N-(5-fluoro-4-methoxy-2-nitrophenyl)acetamide 
• 155020-43-2 3-<(diethylamino)methyl>-5-fluoro-4-hydroxyacetanilide 
• 1025986-25-7 4-Amino-2-diethylaminomethyl-6-fluoro-phenol 

Relevant articles and documents

High Turnover Pd/C Catalyst for Nitro Group Reductions in Water. One-Pot Sequences and Syntheses of Pharmaceutical Intermediates

Commercially available Pd/C can be used as a catalyst for nitro group reductions with only 0.4 mol % Pd loading. The reaction can be performed using either silane as a transfer hydrogenating agent or simply a hydrogen balloon (μ1 atm pressure). With this technology, a series of nitro compounds was reduced to the desired amines in high chemical yields. Both the catalyst and surfactant were recycled several times without loss of reactivity.

Benzimidazole compound, and preparation method, intermediate and application thereof

The invention discloses a benzimidazole compound, and a preparation method, an intermediate and an application thereof. The invention provides a benzimidazole compound A or a pharmaceutically-acceptable salt thereof, and also provides an application of th

Pd-catalyzed ortho-selective oxidative coupling of halogenated acetanilides with acrylates

Coupling of different halogenated acetanilides with acrylates using Pd-catalyzed ortho-selective C-H bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron-rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions.