SR-18292

Base Information

• Chemical Name: SR-18292
• CAS No.: 2095432-55-4
• Molecular Formula: C₂₃H₃₀N₂O₂
• Molecular Weight: 366.503
• Mol file: 2095432-55-4.mol

Synonyms:

Chemical Property of SR-18292

Chemical Property:

• Boiling Point: 553.6±50.0 °C(Predicted)
• PKA: 13.90±0.20(Predicted)
• Density: 1.132±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

SR18292 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: SR 18292 is a novel selective inhibitor of PGC-1alpha Gluconeogenic Activity.

Technology Process of SR-18292

There total 3 articles about SR-18292 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 1-((1H-indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)-propan-2-ol (2095432-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 12 h / 80 °C

1.2: 6 h / 20 °C

2.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 130 °C

With potassium carbonate; potassium iodide; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/acs.jmedchem.0c01450

Reference yield:

N-(4′-methylbenzyl)-2-methylpropan-2-amine (55980-45-5) → 1-((1H-indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)-propan-2-ol (2095432-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 130 °C

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/acs.jmedchem.0c01450

Reference yield:

1H-indol-4-ol (2380-94-1) + 2-methyl-N-(4-methylbenzyl)-N-(oxiran-2-ylmethyl)propan-2-amine → 1-((1H-indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)-propan-2-ol (2095432-55-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 12h;

DOI:10.1021/acs.jmedchem.0c01450

upstream raw materials:

1H-indol-4-ol

N-(4′-methylbenzyl)-2-methylpropan-2-amine

4-methyl-benzaldehyde

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