N-(tert-butyl)-N-(4-methylbenzyl)amine

Base Information

• Chemical Name: N-(tert-butyl)-N-(4-methylbenzyl)amine
• CAS No.: 55980-45-5
• Molecular Formula: C12H19N
• Molecular Weight: 177.29
• Mol file: 55980-45-5.mol

Synonyms:N-(tert-butyl)-N-(4-methylbenzyl)amine;AKOS BBV-014210;N-(4-METHYLPHENYLMETHYL)TERT-BUTYLAMINE;UKRORGSYN-BB BBV-014210

Chemical Property of N-(tert-butyl)-N-(4-methylbenzyl)amine

Chemical Property:

• Boiling Point: 242.5±9.0 °C(Predicted)
• PKA: 10.00±0.29(Predicted)
• PSA: 12.03000
• Density: 0.900±0.06 g/cm3(Predicted)
• LogP: 3.27400

Purity/Quality:

99% ^*data from raw suppliers

N-(TERT-BUTYL)-N-(4-METHYLBENZYL)AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(tert-butyl)-N-(4-methylbenzyl)amine

There total 11 articles about N-(tert-butyl)-N-(4-methylbenzyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Methylbenzyl alcohol (589-18-4) + tert-butylamine (75-64-9) → N-(4′-methylbenzyl)-2-methylpropan-2-amine (55980-45-5)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; at 80 ℃; for 1h;

DOI:10.1021/ol034806q

Reference yield: 82.0%

4-methyl-benzaldehyde (104-87-0) + tert-butylamine (75-64-9) → N-(4′-methylbenzyl)-2-methylpropan-2-amine (55980-45-5)

Guidance literature:

4-methyl-benzaldehyde; tert-butylamine; With methanol; at 20 ℃; for 1h;

With methanol; sodium tetrahydroborate; at 0 - 20 ℃;

Reference yield: 82.0%

N-tert-butyl-N-(4-methylbenzyl)-3-phenylprop-2-yn-1-amine → N-(4′-methylbenzyl)-2-methylpropan-2-amine (55980-45-5)

Guidance literature:

N-tert-butyl-N-(4-methylbenzyl)-3-phenylprop-2-yn-1-amine; With zirconocene dichloride; trimethylaluminum; In hexane; at 40 ℃; for 6h; Inert atmosphere;

With water; In hexane; Cooling with ice;

DOI:10.1007/s11172-020-2723-9

upstream raw materials:

4-Methylbenzyl bromide

tert-butylamine

4-Methylbenzyl alcohol

4-methyl-benzaldehyde

Downstream raw materials:

N-(4-methylbenzyl)-N-tert-butyl-2-oxopropionamide

1-((1H-indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)-propan-2-ol

Refernces

• 1、 Cameron, Michael D.,Griffin, Patrick R.,Kamenecka, Theodore M.,Lin, Hua,Lin, Li,Novick, Scott J.,Puigserver, Pere,Ruiz, Claudia,Sharabi, Kfir,Zhu, Di. "Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production". supporting information. p. 980 - 990. Retrieved 2021/02/01.
• 2、 Friedrich, Alexander,Eyselein, Jonathan,Elsen, Holger,Langer, Jens,Pahl, Jürgen,Wiesinger, Michael,Harder, Sjoerd. "Cationic Aluminium Complexes as Catalysts for Imine Hydrogenation". supporting information. p. 7756 - 7763. Retrieved 2021/04/28.