3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

Base Information

Chemical Name:3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
CAS No.:1874276-76-2
Molecular Formula:C₂₂H₂₃F₃N₈O
Molecular Weight:472.473
Hs Code.:
Mol file:1874276-76-2.mol

Synonyms:

Suppliers and Price of 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
LXS-196 >98%
1 g
$ 2400.00

DC Chemicals
LXS-196 >98%
100 mg
$ 650.00

ChemScene
LXS196 99.68%
50mg
$ 610.00

ChemScene
LXS196 99.68%
25mg
$ 409.00

ChemScene
LXS196 99.68%
10mg
$ 235.00

ChemScene
LXS196 99.68%
5mg
$ 155.00

ChemScene
LXS196 99.68%
2mg
$ 80.00

ChemScene
LXS196 99.68%
100mg
$ 920.00

Biorbyt Ltd
LXS-196 >98%
1 g
$ 3580.20

Biorbyt Ltd
LXS-196 >98%
250 mg
$ 1802.00

Total 13 raw suppliers

Chemical Property of 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

Chemical Property:

Boiling Point:592.7±50.0 °C(Predicted)
PKA:7.65±0.70(Predicted)
Density:1.387±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

LXS-196 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

There total 8 articles about 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: tert-butyl (1-(2-(3-amino-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamido)pyridin-3-yl)-4-methylpiperidin-4-yl)carbamate

: 1874276-76-2
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 22 ℃; for 4h;

Reference yield:

: 54231-35-5
3-fuoro-2-nitropyridine

: 1874276-76-2
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane / 6 h / 100 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol

3.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.67 h / 20 °C

3.2: 16 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 22 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; triethylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: methyl 3-amino-6-(trimethylstannyl)pyrazine-2-carboxylate

: 1874276-76-2
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine; triethylamine / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 1 h / 20 °C

3.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.67 h / 20 °C

3.2: 16 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 22 °C

With 4-methyl-morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; triethylamine; HATU; tris-(o-tolyl)phosphine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;