N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide

Base Information

Chemical Name:N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide
CAS No.:2244579-87-9
Molecular Formula:C₂₁H₂₄BrFN₂O₂
Molecular Weight:435.336
Hs Code.:

Synonyms:

Suppliers and Price of N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
Ec2la ≥98%(HPLC)
50
$ 1004.00

Tocris
Ec2la ≥98%(HPLC)
10
$ 239.00

Biosynth Carbosynth
C2 NEW
50 mg
$ 450.00

Biosynth Carbosynth
C2 NEW
10 mg
$ 125.00

AK Scientific
N-[5-Bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide
50mg
$ 657.00

Total 7 raw suppliers

Chemical Property of N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide

Chemical Property:

Boiling Point:572.4±50.0 °C(Predicted)
Density:1.40±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Ec2la ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide

There total 6 articles about N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: N-(5-bromo-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)-cycloheptane-carboxamide

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 2244579-87-9
N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide

Guidance literature:: N-(5-bromo-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)-cycloheptane-carboxamide; With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

1-chloromethyl-4-fluorobenzene; In N,N-dimethyl-formamide; at 50 ℃; for 12h;
DOI:10.1021/acs.jmedchem.8b00368

Reference yield:

: 21901-18-8
2-hydroxy-4-methyl-3-nitropyridine

: 2244579-87-9
N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium on activated charcoal / methanol / 12 h / 750.08 - 4500.45 Torr

2.1: triethylamine / toluene; N,N-dimethyl-formamide / 48 h

3.1: bromine / chloroform / 12 h / 30 °C

4.1: cesium fluoride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 12 h / 50 °C

With palladium on activated charcoal; hydrogen; bromine; triethylamine; cesium fluoride; In methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.8b00368

Reference yield:

: 33252-54-9
3-amino-2-hydroxy-4-methylpyridine

: 2244579-87-9
N-[5-bromo-1,2-dihydro-1-(4'-fluorobenzyl)-4-methyl-2-oxopyridin-3yl]cycloheptanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / toluene; N,N-dimethyl-formamide / 48 h

2.1: bromine / chloroform / 12 h / 30 °C

3.1: cesium fluoride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 12 h / 50 °C

With bromine; triethylamine; cesium fluoride; In chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.8b00368