N-(2-methoxyphenyl)-2-naphthalen-2-yloxyacetamide

Base Information

Chemical Name:N-(2-methoxyphenyl)-2-naphthalen-2-yloxyacetamide
CAS No.:551913-68-9
Molecular Formula:C₁₉H₁₇NO₃
Molecular Weight:307.349
Hs Code.:
DSSTox Substance ID:DTXSID101326321
ChEMBL ID:CHEMBL1368896
Mol file:551913-68-9.mol

Synonyms:N-(2-methoxyphenyl)-2-naphthalen-2-yloxyacetamide;N-(2-methoxyphenyl)-2-(2-naphthyloxy)acetamide;551913-68-9;MLS001078593;CHEMBL1368896;DTXSID101326321;HMS2970E09;AKOS001326953;SMR000708285;AG-670/36580045;Z19834783

Suppliers and Price of N-(2-methoxyphenyl)-2-naphthalen-2-yloxyacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-methoxyphenyl)-2-naphthalen-2-yloxyacetamide

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:307.12084340
Heavy Atom Count:23
Complexity:387

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1NC(=O)COC2=CC3=CC=CC=C3C=C2

Technology Process of N-(2-methoxyphenyl)-2-naphthalen-2-yloxyacetamide

There total 3 articles about N-(2-methoxyphenyl)-2-naphthalen-2-yloxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 120-23-0
(2-naphthoyl)oxyacetic acid

: 90-04-0
2-methoxy-phenylamine

: 551913-68-9
N-(2-methoxyphenyl)-2-(naphthalen-2-yloxy)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃;
DOI:10.1002/cbdv.201800577

Reference yield:

: 6036-14-2
ethyl (naphthalen-2-yloxy)acetate

: 551913-68-9
N-(2-methoxyphenyl)-2-(naphthalen-2-yloxy)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 0.5 h / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1002/cbdv.201800577

Reference yield:

: 135-19-3
β-naphthol

: 551913-68-9
N-(2-methoxyphenyl)-2-(naphthalen-2-yloxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C

2: sodium hydroxide / ethanol / 0.5 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201800577