(2-Naphthyloxy)acetic acid ethyl ester

Base Information

• Chemical Name: (2-Naphthyloxy)acetic acid ethyl ester
• CAS No.: 6036-14-2
• Molecular Formula: C14H14 O3
• Molecular Weight: 230.263
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID80209130
• Wikidata: Q83083303
• Mol file: 6036-14-2.mol

Synonyms:(2-naphthyloxy)acetic acid ethyl ester;ethyl (2-naphthyloxy)acetate

Chemical Property of (2-Naphthyloxy)acetic acid ethyl ester

Chemical Property:

• Vapor Pressure: 3.61E-05mmHg at 25°C
• Boiling Point: 353.4°C at 760 mmHg
• Flash Point: 147.1°C
• PSA: 35.53000
• Density: 1.148g/cm³
• LogP: 2.78170
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 230.094294304
• Heavy Atom Count: 17
• Complexity: 252

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC2=CC=CC=C2C=C1

Technology Process of (2-Naphthyloxy)acetic acid ethyl ester

There total 7 articles about (2-Naphthyloxy)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl bromoacetate (105-36-2) + β-naphthol (135-19-3) → ethyl (naphthalen-2-yloxy)acetate (6036-14-2)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Reflux;

DOI:10.1016/j.ejmech.2012.09.040

Reference yield: 88.0%

chloroacetic acid ethyl ester (105-39-5) + β-naphthol (135-19-3) → ethyl (naphthalen-2-yloxy)acetate (6036-14-2)

Guidance literature:

With potassium carbonate; In acetone; for 10h; Reflux;

DOI:10.1016/j.bmcl.2020.127743

Reference yield: 68.0%

(2-naphthoyl)oxyacetic acid (120-23-0) + ethanol (64-17-5) → ethyl (naphthalen-2-yloxy)acetate (6036-14-2)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.14233/ajchem.2021.22912

upstream raw materials:

(2-naphthoyl)oxyacetic acid

ethanol

sodium 2-naphtholate

chloroacetic acid ethyl ester

Downstream raw materials:

C₁₉H₁₆ClN₃O₂S

5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione

1-([2]-naphthyloxy-acetyl)-4-phenyl thiosemicarbazide

5-trifluoromethyl-5-hydroxy-4,5-dihydro-3-phenyl-1H-1-(2-naphthoxyacetyl)pyrazole

Refernces

• 1、 Al-Ostoot, Fares Hezam,Ara Khanum, Shaukath,Grisha, S.,Mohammed, Yasser Hussein Eissa,Vivek, H. K.,Zabiulla. "Molecular docking and synthesis of caffeic acid analogous and its anti-inflammatory, analgesic and ulcerogenic studies". . . Retrieved 2020/12/25.
• 2、 Su, Yingpeng,Ma, Chenglong,Zhao, Yanan,Yang, Caixia,Feng, Yawei,Wang, Ke-Hu,Huang, Danfeng,Huo, Congde,Hu, Yulai. "Regioselective synthesis of spiro naphthofuranone-pyrazoline via a [3+2] cycloaddition of benzoaurones with nitrile imines". supporting information. . Retrieved 2020/07/08.