(E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide

Base Information

• Chemical Name: (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide
• CAS No.: 204857-45-4
• Molecular Formula: C₁₅H₁₃ClN₂O₄S
• Molecular Weight: 352.798
• Mol file: 204857-45-4.mol

Synonyms:

Chemical Property of (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide

Chemical Property:

Purity/Quality:

(E)-N-(4-CHLOROBENZYL)-2-(4-NITROPHENYL)-1-ETHENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide

There total 3 articles about (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-nitrobenzaldehdye (555-16-8) + N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide (204857-35-2) → (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide (204857-45-4)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; 1.) -78 deg C, 1 h, 2.) -78 to 20 deg C, 18 h;

DOI:10.1055/s-1998-1609

Reference yield:

N-(4-chloro-benzyl)-methanesulfonamide (42060-30-0) → (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide (204857-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP / CH₂Cl₂

2: 69 percent / t-BuOK / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 to 20 deg C, 18 h

With dmap; potassium tert-butylate; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-1998-1609

Reference yield:

4-chlorobenzylamine (104-86-9) → (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide (204857-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: DMAP / CH₂Cl₂

3: 69 percent / t-BuOK / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 to 20 deg C, 18 h

With dmap; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-1998-1609

upstream raw materials:

4-nitrobenzaldehdye

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

N-(4-chloro-benzyl)-methanesulfonamide

4-chlorobenzylamine