N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide
• CAS No.: 204857-35-2
• Molecular Formula: C₁₃H₁₈ClNO₄S
• Molecular Weight: 319.809
• Mol file: 204857-35-2.mol

Synonyms:N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

Chemical Property of N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

Chemical Property:

Purity/Quality:

TERT-BUTYL N-(4-CHLOROBENZYL)-N-(METHYLSULFONYL)CARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

There total 2 articles about N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

di-tert-butyl dicarbonate (24424-99-5) + N-(4-chloro-benzyl)-methanesulfonamide (42060-30-0) → N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide (204857-35-2)

Guidance literature:

With dmap; In dichloromethane; for 0.5h;

DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

4-chlorobenzylamine (104-86-9) → N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide (204857-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / Et₃N / CH₂Cl₂ / 2 h

2: 89 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h

With dmap; triethylamine; In dichloromethane;

DOI:10.1016/S0968-0896(01)00295-4

Reference yield: 99.0%

3-phenyl-propenal (104-55-2) + N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide (204857-35-2) → (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide (204857-48-7)

Guidance literature:

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 1h;

3-phenyl-propenal; In tetrahydrofuran; at -78 - 20 ℃; for 18h; Further stages.;

DOI:10.1021/ol006863e

upstream raw materials:

di-tert-butyl dicarbonate

N-(4-chloro-benzyl)-methanesulfonamide

4-chlorobenzylamine

Downstream raw materials:

(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide

Carbonic acid tert-butyl ester 1-[(4-chloro-benzylsulfamoyl)-methyl]-decyl ester

(E)-2-(4-Nitro-phenyl)-ethenesulfonic acid 4-chloro-benzylamide

(E)-Buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide

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