4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Base Information

Chemical Name:4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid
CAS No.:1360821-25-5
Molecular Formula:C₃₀H₂₉Cl₂FN₄O₅
Molecular Weight:615.488
Hs Code.:

4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

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Chemical Property of 4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

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Technology Process of 4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

There total 4 articles about 4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136888-12-5
6-chloro-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

: 1360821-24-4
4-((2S,3S,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

: 1360821-25-5
4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / methanol / 50 °C

2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

2.2: 40 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

4.1: Waters/Thar Multi-Gram II, Chiral Technologies, Diacel OD, 3*25 cm / ethanol; carbon dioxide / 35 °C / 75007.5 Torr / Resolution of racemate

With piperidine; lithium hydroxide monohydrate; water; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; carbon dioxide;

Reference yield:

: methyl racemic-4-((2S,3S,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

: 1360821-24-4
4-((2S,3S,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

: 1360821-25-5
4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

2: Waters/Thar Multi-Gram II, Chiral Technologies, Diacel OD, 3*25 cm / ethanol; carbon dioxide / 35 °C / 75007.5 Torr / Resolution of racemate

With lithium hydroxide monohydrate; water; In tetrahydrofuran; ethanol; carbon dioxide;

Reference yield:

: 85070-48-0
2-fluoro-3-chlorobenzaldehyde

: 1360821-24-4
4-((2S,3S,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

: 1360821-25-5
4-((2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / methanol / 50 °C

2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

2.2: 40 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

4.1: Waters/Thar Multi-Gram II, Chiral Technologies, Diacel OD, 3*25 cm / ethanol; carbon dioxide / 35 °C / 75007.5 Torr / Resolution of racemate

With piperidine; lithium hydroxide monohydrate; water; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; carbon dioxide;