Technology Process of (2-(Chloromethyl)-4-(dibenzylamino)phenyl)methanol hydrochloride
There total 4 articles about (2-(Chloromethyl)-4-(dibenzylamino)phenyl)methanol hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 23 - 40 °C / 3102.97 Torr / Inert atmosphere
2.1: potassium phosphate; potassium iodide / water; N,N-dimethyl acetamide / 2.83 h / 60 - 90 °C
3.1: lithium aluminium tetrahydride; water / tetrahydrofuran / 20.5 h / -50 - 20 °C / Cooling with acetone-dry ice
4.1: thionyl chloride / acetonitrile / 1.5 h / 18 °C / Cooling with ice
4.2: 2 h / 23 °C
With
potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; potassium iodide;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C
2: potassium carbonate / N,N-dimethyl acetamide / 15 h / 90 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / -20 - 10 °C / Inert atmosphere
4: thionyl chloride / acetonitrile / 0.17 h / 0 - 25 °C / Inert atmosphere
With
lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium carbonate;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl acetamide / 15 h / 90 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / -20 - 10 °C / Inert atmosphere
3: thionyl chloride / acetonitrile / 0.17 h / 0 - 25 °C / Inert atmosphere
With
lithium aluminium tetrahydride; thionyl chloride; potassium carbonate;
In
tetrahydrofuran; N,N-dimethyl acetamide; acetonitrile;