610-22-0

Basic information

• Product Name: Dimethyl 4-nitrophthalate
• Synonyms: DIMETHYL 4-NITROBENZENE-1,2-DICARBOXYLATE;DIMETHYL 4-NITROPHTHALATE;4-NITROPHTHALIC ACID DIMETHYL ESTER;1,2-Benzenedicarboxylic acid, 4-nitro-, dimethyl ester;2-benzenedicarboxylicacid,4-nitro-dimethylester;Phthalic acid, 4-nitro-, dimethyl ester;4-Nitrobenzene-1,2-dicarboxylic acid dimethyl ester;5-NITROISOPHTHYL ACID DIMETHYL ESTER
• CAS NO: 610-22-0
• Molecular Formula: C₁₀H₉NO₆
• Molecular Weight: 239.18
• EINECS: 210-212-7
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Esters;C10 to C11;Carbonyl Compounds;Esters
• Mol File: 610-22-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 64-66 °C(lit.)
• Boiling Point: 192-195 °C25 mm Hg(lit.)
• Flash Point: 192-195°C/25mm
• Appearance: /
• Density: 1.4504 (rough estimate)
• Vapor Pressure: 0.000462mmHg at 25°C
• Refractive Index: 1.5310 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Sparingly)
• BRN: 1886234
• CAS DataBase Reference: Dimethyl 4-nitrophthalate(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl 4-nitrophthalate(610-22-0)
• EPA Substance Registry System: Dimethyl 4-nitrophthalate(610-22-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 610-22-0(Hazardous Substances Data)

Usage

Uses

1,2-Dimethyl 4-nitrophthalate is a key intermediate for the synthesis of N-?hydroxyphthalimide.

InChI:InChI=1/C10H9NO6/c1-16-9(12)7-4-3-6(11(14)15)5-8(7)10(13)17-2/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 75-75-2 methanesulfonic acid 
• 610-27-5 4-nitrophthalic acid 
• 131-11-3 phthalic acid dimethyl ester 
• 24564-72-5 4-nitrophthalic acid chloride 

Downstream Products

• 51832-31-6 4-amino-phthalic acid dimethyl ester 
• 39617-05-5 4-dimethylamino-phthalic acid dimethyl ester 
• 1260403-55-1 [2-(chloromethyl)-4-(dibenzylamino)phenyl]methanol hydro chloride 
• 52412-60-9 dimethyl 3,4-diaminophthalate 
• 52412-57-4 4,5-diaminophthalic acid dimethyl ester 
• 52412-59-6 3-Nitro-4-amino-phthalsaeure-dimethylester 
• 52412-56-3 dimethyl 4-acetamido-3-nitrophthalate 
• 52412-55-2 dimethyl 4-acetamido-5-nitrophthalate 

Relevant articles and documents

A High Selective Chemiluminescent Probe Derived from Iso-luminol Enabling High Sensitive Determination of Ferrous Ions in the Environmental Waters

A new chemiluminescence (CL) reagent named 4-amino-5-thiocyanato-phthalyl-hydrazine (iso-luminol-SCN) is synthesized by the bromide-mediated substitution reaction of iso-luminol with sodium thiocyanate in dimethyl formamide (DMF) at room temperature. Stro

HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein HET, R1, R2, R3, R4, R5, L, L1, X1, X2, X3 and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1, R2, R4, R5, R6, R7, R8, R9, R10,Z, X1, X2, X3, L2, HET, n and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.